|
|
|
| Analysis of the Application Effect of Glucocorticoids in the Treatment of Children with Refractory Pneumonia and Mycoplasma Pneumonia |
| SONG Xiaotong |
| Xuzhou Center Hospital Children's Diagnosis and Treatment Center, Jiangsu Xuzhou 221009, China |
|
|
|
|
Abstract Objective: To investigate the effect of glucocorticoids in the treatment of children with refractory pneumonia and mycoplasma pneumonia. Methods: 200 children with refractory pneumonia and mycoplasma pneumonia admitted from February 2016 to February 2018 were randomly divided into two groups. The control group was given routine treatment. The glucocorticoid group was given glucocorticoids. Hormones, hospital-related indicators, lung function, inflammatory markers, immune parameters, imaging findings, and adverse reactions were compared between the two groups. Results: The time of fever, total fever, cough remission, total cough time, antibiotic use time, and number of relapses were significantly lower in the glucocorticoid group than in the control group; FVC, FEV1, PEF, and FEF25 after treatment. , FEF75, IgG, CD3+/CD4+ and CD3+/CD8+ levels were significantly higher than the control group, WBC and CRP levels were significantly lower than the control group; overall imaging examination results were significantly better than the control group, the difference has Statistical significance (P<0.05); There was no statistically significant difference in drug adverse reaction rate between the two groups of children (P>0.05). Conclusion: The application of glucocorticoids in the treatment of children with refractory pneumonia caused by mycoplasma pneumonia is effective, with high safety and useful for reference.
|
|
|
|
|
|
[1] 安建光.糖皮质激素联合胸腺肽治疗儿童难治性支原体肺炎的临床分析[J].延安大学学报(医学科学版),2017,15(1):65~67.
[2] 陈莉莉,刘金荣,赵顺英,等.常规剂量甲泼尼龙治疗无效的儿童难治性肺炎支原体肺炎的临床特征和治疗探讨[J].中华儿科杂志,2014,52(3):172~176.
[3] Yan Y,Wei Y,Jiang W,et al.The clinical characteristics of corticosteroid-resistant refractory mycoplasma pneumoniae pneumonia in children[J].Sci Rep,2016,6:39929.
[4] 张学萍,夏小燕.小剂量糖皮质激素治疗儿童难治性支原体肺炎的临床疗效及对C反应蛋白的影响[J].中国基层医药,2014,21(20):3177~3178.
[5] Huang L,Chen H,Peng S.Spontaneous pneumomediastinum,emphysema,and pulmonary bullae associated with refractory mycoplasma pneumoniae pneumonia in a child[J].Pediatr Pulmonol,2017,52(10):E77~E80.
[6] 李兵娜.难治性肺炎支原体肺炎46例临床特点及早期诊治[J].河南科技大学学报(医学版),2015,33(3):202~203.
[7] Matsuda Y,Chigusa Y,Kondoh E,et al.A case of macrolide-refractory mycoplasma pneumoniae pneumonia in pregnancy treated with garenoxacin[J].Case Rep Obstet Gynecol,2017,2017:3520192.
[8] 林志雄,王开梅,陈江,等.不同剂量糖皮质激素辅助治疗小儿难治性肺炎支原体肺炎合并肺外并发症疗效比较[J].中国医院药学杂志,2017,37(7):639~642. |
|
|
|
2018, Vol. 24 
