|
|
|
| Expression of Soluble Co-stimulatory Molecule B7-H4 in Serum of Patients with Precancerous Lesions of Esophagus |
| CHEN Xinran, et al |
| The Fourth Hospital of Hebei Medical University, Hebei Shijiazhuang 050011, China |
|
|
|
|
Abstract Objective: To study the expression of soluble costimulatory molecule B7 homologue 4 (sB7-H4) in sera of patients, in order to investigate the clinical significance of sB7-H4 in the diagnosis of esophageal precancerous condition. Methods: Esophageal pathological changes were evaluated by hematoxylin-eosin (HE) staining. sB7-H4 and squamous cell carcinoma antigen-2 (SCCA-2) concentrations were detected by enzyme-linked immunosorbent assay (ELISA). Results: The precancerous lesions of the esophagus were divided into low grade intraepithelial neoplasia (LGIN) and high grade intraepithelial neoplasia (HGIN). The serum SCCA-2 concentration in HGIN patients was significantly higher than that in LGIN patients and healthy subjects (SCCA-2, P<0.01, P<0.01). The serum sB7-H4 concentration in LGIN patients was significantly higher than that in healthy subjects (sB7-H4) (P<0.05), and significantly lower than that in HGIN patients (P<0.01). The expression of sB7-H4 in serum was positively correlated with the histopathological grade of esophagus (P<0.0001), but not related to age and sex (P=0.7777, P=0.6068). Conclusion: The concentration of serum sB7-H4 increased progressively in the course of precancerous lesions of the esophagus. sB7-H4 is a valuable serum marker for judging the progression of precancerous lesions.
|
|
|
|
|
|
[1] Stewart BW, wild CP. World cancer report 2014[M]. Lyon: International Agency for Research on Cancer, 2014.374~382.
[2] 乔友林.食管癌流行病学研究的重要里程碑[J].中国肿瘤临床,2016,43(12):500~501.
[3] Rice T, Ishwaran H, Hofstetter W, et al. Esophageal cancer: associations with (pN+) lymph node metastases[J]. Ann Surg, 2017, 265(1): 122~129.
[4] Gal B, Mrzena L, Hort P. Precancerous conditions in the ENT area[J]. Klin Onkol, 2013, 26 Suppl: S13~16.
[5] 孙益峰,唐东方,高文,等.早期和浅表性食管鳞状细胞癌的内镜下治疗进展[J].中华胸部外科电子杂志,2017,4:239~243.
[6] Zhang L, Wu H, Lu D, et al. The costimulatory molecule B7-H4 promote tumor progression and cell proliferation through translocating into nucleus[J]. Oncogene, 2013, 32(46): 5347~5358.
[7] 马路,折占飞.鳞状细胞癌抗原研究进展[J].疾病监测与控制杂志,2013,7(3):159~160.
[8] Shi Q, Ju H, Yao LQ, et al. Risk factors for postoperative stricture after endoscopic submucosal dissection for superficial esophageal carcinoma[J]. Endoscopy, 2014, 46(8): 640~644.
[9] Shi HB, Ji M, Wu J, et al. Serum B7-H4 expression is a significant prognostic indicator for patients with gastric cancer[J]. World Surg Oncol, 2014, 12: 188.
[10] 李春仙,李美红,王峰,等.非小细胞肺癌患者血清可溶性B7-H4检测的临床意义[J].中国卫生检验杂志,2015,10:1582~1583. |
|
|
|
2018, Vol. 24 
