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| Risk Factors of Hypertensive Disorders of Pregnancy and the Effectsof Target Organ Damage |
| YIN Xue, et al |
| University of Jinan-Shandong Academy of Medical Sciences,Shandong Jinan 250062, China |
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Abstract Objective: To investigate the risk factors of hypertensive disorders of pregnancy (HDP) and the association between gestational hypertension and target organ damage. Methods: From Oct 2015 to Oct 2017, 1468 pregnancy women were enrolled in Xintai People's Hospital. Clinical data, such as age, pre-pregnancy body mass index(BMI), blood pressure and family history of HDP were collected. Left ventricular hypertrophy was assessed by left ventricular mass index (LVMI) using cardiac color Doppler ultrasound. Estimate glomerular filtration rate (eGFR) was calculated base on the level of serum creatinine. Their clinical data were analyzed and logistic regression model was made to determine risk factors of HDP. Multivariate linear regression analysis was made to determine the independent influencing factors of LVMI and eGFR. Results: The prevalence of HDP was 5.18% among 1468 pregnancy women. Age (OR=3.071, 95%CI: 1.583-5.957), pre-pregnancy BMI (OR=1.213, 95%CI: 1.064-1.382), pre-pregnancy anxiety (OR=1.684, 95%CI: 1.164-2.435) and family history of HDP (OR=2.678, 95%CI: 1.446-4.957) were independent risk factors of HDP (P<0.05). Twenty-four-hour systolic blood pressure and diastolic blood pressure were positively correlated with LVMI (correlation coefficients were 0.736 and 0.702, respectively, all P<0.001) and negatively correlated with eGFR (correlation coefficients were -0.696 and -0.633, respectively, all P<0.001). After adjustment for confunders, 24-hour systolic blood pressure and diastolic blood pressure were independently and significantly associated with LVMI and eGFR (all P<0.05). Conclusion: Advanced age, pre-pregnancy BMI, pre-pregnancy anxiety and family history of HDP were independent risk factors of HDP. However, HDP played a crucial and independent role of target organ damage.
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[1] Middeke M. Hypertensive disorders in pregnancy[J]. Dtsch Med Wochenschr, 2016, 141(18):1287~1294.
[2] 中华医学会妇产科学分会妊娠期高血压疾病学组.妊娠期高血压疾病诊治指南(2015)[J].中华妇产科杂志,2015,50(10):721~728.
[3] 沈卓之,丁贤彬,毛德强,等.重庆市2014年成年人吸烟、戒烟行为及认知现状调查[J].中华流行病学杂志,2015,36(11):1236~1243.
[4] Kocsis R N. Diagnostic and statistical manual of mental disorders fifth edition (DSM-V)[J]. International Journal of Offender Therapy & Comparative Criminology, 2013, 57(12):1546~1548.
[5] 杨慧霞.妊娠合并糖尿病临床诊断与治疗推荐指南(草案)[J].中国实用妇科与产科杂志,2007,6(6):310~312.
[6] 陈荟荷,孙燕淑,刘梅林.老年高血压患者动态动脉硬化指数与左心室质量指数的相关性[J].中华心血管病杂志,2016,44(9):750~753.
[7] 林彤,陈丽红,胡继芬,等.妊娠期高血压的危险因素[J].中华高血压杂志,2015(1):83~85.
[8] Masho SW, Urban P, Cha S, et al. Body mass index, weight gain, and hypertensive disorders in pregnancy[J]. Am Hypertens, 2016, 29(6):763~771.
[9] Thombre MK, Talge NM, Holzman C. Association between pre-pregnancy depression/anxiety symptoms and hypertensive disorders of pregnancy[J].Womens Health, 2015, 24(3):228~236.
[10] 顾颖, 冯亚玲,许倩.妊娠期高血压疾病的相关危险因素分析[J].中国卫生统计,2017,34(4):618~619.
[11] 陈艳,沈飞霞,陈思思,等.80岁及以上老年住院患者肾功能及相关危险因素分析[J].中华老年医学杂志,2015,34(5):530~533. |
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2018, Vol. 24 
