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| Effect of Nimodipine combined with Fasudil Hydrochloride SAC Vasospasm of Postoperative Acute Hemorrhage of Intracranial Aneurysm |
| WU Jie, ZHOU Ye |
| The People's Hospital of Qionghai, Hainan Qionghai 571400, China |
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Abstract Objective: To evaluate the effect of Nimodipine combined with Fasudil hydrochloride in the treatment of Cerebral vasospasm of intracranial aneurysms after acute hemorrhagic by SAC after operation. Methods: A total of 86 patients with crebral vasospasm of intracranial aneurysms after acute hemorrhagic by SAC were selected and randomly divided into 2 groups, 43 cases each. The control group received nimodipine infusion micro pump injection 10mg, tid, the treatment group received nimodipine infusion micro pump injection 10mg, tid,+ fasudil hydrochloride micro pump injection 30mg, tid, and 2 groups were treated for 14days. Nerve function defect score (National Institutes of health neurological impairment score, NIHSS), Glasgow coma score (Glasgow Coma Scale, GCS), Barthel (the Barthel index of index ADL) evaluated, blood samples were collected to determine the levels of Fatty acid binding protein (FABP) and Neuron specific enolase (NSE), and blood flow velocity of middle cerebral artery (MCA) were determined and clinical effect were also compared. Results: After the treatment, the NIHSS scores in the control group and the treatment group were (10.97±3.98), (7.61±3.86), GCS scores were (11.19±2.85), (13.56±3.04) Barthel scores were respectively (48.37±11.24), (59.68±12.30), levels of FABP (521.23±118.75), (397.02±97.45) ng/L, NSE were respectively (14.82±3.71), (11.64±3.59) ug/L, MCA were respectively (123.20±21.14), (138.69±21.36) cm/s, the above indexes in the control group and treatment group had statistical significance (P<0.05), the total efficiency of the control group76.74% was lower than the treatment group 93.02% (P<0.05), and the incidence of cerebral infarction within 30 days in the control group18.60% was higher than the treatment group 4.65%(P<0.05). Conclusion: Nimodipine combined with fasudil hydrochloride can relieve cerebral vasospasm of intracranial aneurysms after acute hemorrhagic by SAC, reduce neurological damage, promote brain perfusion, is worthy of clinical application.
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2018, Vol. 24 
