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| The Application of Carbon Nanoparticle in VI Region Lymph Nodes Dissection and Parathyroid Gland Protection for Patients with cN0 Papillary Thyroid Carcinoma |
| ZHANG Chuanzhuo, LI Jiangli |
| Jiangsu Traditional Chinese Medicine Hospital, Jiangsu Nanjing 210000, China |
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Abstract Objective: To study the application of carbon nanoparticle in VI region lymph nodes dissection and parathyroid gland protection for patients with cN0 papillary thyroid carcinoma. Methods: 79 cases of cN0 thyroid papillary carcinoma admitted to Department of general surgery in Jiangsu Province Traditional Chinese Medicine Hospital from July 2016 to July 2017 were randomly divided into nano carbon group (41 cases) and control group (38 cases). The general situation of the two groups was compared. Comparative analysis of two groups of patients after obtaining the average total number of lymph nodes, the diameter of >1.0cm, 0.5~1.0cm and <0.5cm lymph node number and the number of metastatic lymph nodes and lymph node metastasis rate, detection rate, pathological parathyroid first day after the operation, PTH and blood Ca, operation time, postoperative drainage. Results: There was no significant difference in the general condition between the carbon nanoparticle trace group and the control group. Comparative analysis of two groups of patients after obtaining the average total number of lymph nodes, the diameter of >1.0cm, 0.5~1.0cm and <0.5cm lymph node number and the number of metastatic lymph nodes and lymph node metastasis rate, detection rate, pathological parathyroid first day after the operation, PTH and blood Ca, operation time, postoperative drainage. There was no difference between the operation time and the postoperative flow rate. Conclusion: Nano carbon can increase the number of lymph node dissection and the number of positive lymph nodes in VI area of cN0 thyroid papillary carcinoma, especially the smaller diameter lymph nodes. It can improve the detection rate of lymph node metastasis, reduce parathyroid damage and reduce the temporary low PTH rate after operation.
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[1] 李治,屈新才,程波,等.乳头状甲状腺癌淋巴结转移特点与中央组淋巴结清扫的临床意义[J].中华外科杂志,2008,46(18):1407~1409.
[2] 高庆军,王南鹏,赵代伟.cN0期甲状腺乳头状微小癌中央区淋巴结隐性转移危险因素[J].中国普通外科杂志,2015,24(11):1504~1510.
[3] 黄国平,蔡铭智,蔡丽生.颈内静脉旁淋巴结活检在甲状腺癌手术中的应用[J].中国普通外科杂志,2013,22(5):593~596.
[4] Li N,Du XL,Reitzel LR,Xu L,et al. Impact of enhanceddetection on the increase in thyroid cancer incidenceinthe United States:Review of incidence trends by socioeconomicstatus within the surveillance,epidemiology,andend results registry,1980~2008[J]. Thyroid,2013,23(1):103~110.
[5] Zhang L, Wei WJ, Ji QH, et al. Risk factors for neck nodal metastasisinpapillary thyroid microcarcinoma: a study of 1066 patients[J].Clin Endocrinol Metab,2012,97(4):1250~1257.
[6] Moo TA, McGill J, Allendorf J, et al. Impact of prophylactic central neck lymph node dissection on early recurrence in papillary thyroidcarcinoma[J]. World Surg, 2010, 34(6):1187~1191.
[7] Bolland MJ,Avenell A,Baron JA,et al. Effect of calcium supplements on risk of myocardial infarction and cardiovascularevents: meta-analysis[J]. BMJ,2010,341:c3691.
[8] Kaptein S,Risselada AJ,Boerma EC,et al. Life- threateningcomplications of vitamin D intoxication due to over-the-countersupplements[J]. ClinToxicol (Phila),2010,48(5):460~462.
[9] Hao RT, Chen J, Zhao LH, et al. Sentinel lymph node biopsy usingcarbon nanoparticles for Chinese patients with papillary thyroidmicrocarcinoma[J]. Eur SurgOncol, 2012, 38(8):718~724.
[10] Magrez A, Kasas S, Salicio V, et al. Cellular toxicity of carbonbasednanomaterials[J]. Nano Lett,2006, 6(6):1121~1125.
[11] 陈万志,吕云霞,谢嵘纳,等.纳米碳在甲状腺癌手术中甲状旁腺保护的应用[J].临床耳鼻咽喉头颈外科杂志,2014,28(24):1918~1924.
[12] 黄国平,蔡铭智,陈培臻.甲状腺癌术后低钙血症探讨[J].实用医学杂志,2009,25(15):2501~2502.
[13] 陈光裕,陈治龙,田永波.纳米碳在甲状腺癌手术中的应用研究[J].中国地方病防治杂志,2017,2(32):177~178. |
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2018, Vol. 24 
