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| Effects of Azithromycin Combined with Pulmicort Respiratory Aspiration on Mycoplasma Pneumoniae Infection in Children and ts Effect on Immune Function |
| YUAN Ling |
| Xuzhou Municipal Hospital Affiliated to Xuzhou Medical University, Jiangsu Xuzhou 221002, China |
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Abstract Objective: To study the effects of azithromycin combined with pulmicort respiratory aspiration on mycoplasma pneumoniae infection in children and its effect on immune function. Methods: 90 children with mycoplasma pneumonia diagnosed in our hospital were randomly divided into observation group and control group, 45 cases in each group. The observation group was treated with azithromycin and pulmicort Respiratory inhalation. The control group was treated with azithromycin alone. Observe and compared the time of complete disappearance of symptoms, changes in serum immunoglobulin (Ig) values, changes in T lymphocyte subsets, changes in hs-CRP and cytokines, and adverse events. occurrence in the two groups. Results: After treatment, the time of fever, cough, sputum, chest tightness, wheezing and lung tribal sounds disappeared in the observation group, which was significantly lower than that in the control group (P<0.05). The Ig values of the two groups were increased to varying degrees, and the increase in the observation group was significantly greater than that in the control group. The difference was statistically significant (P<0.05). After treatment, the levels of CD3+, CD4+, and CD4+/CD8+ increased in different degrees in both groups, and CD8+ decreased. The increase and decrease in the observation group were significantly greater than those in the control group, with a significant difference (P<0.05). The levels of hs-CRP and IL-6 in both groups were decreased, and the decrease in the observation group was significantly greater than that in the control group (P<0.05). Both groups had adverse reactions such as nausea, vomiting and abdominal pain, but the incidence of adverse reactions was significantly lower in the observation group than in the control group (P<0.05). Conclusion: Compared to azithromycin alone, the use of azithromycin combined with Pulmicort Respiratory Inhalation for the treatment of children with Mycoplasma pneumoniae infection can relieve the symptoms of children quickly disappear, and can improve the immune function of children with no serious adverse reactions. It is worth in clinical application.
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2018, Vol. 24 
