清开灵滴丸治疗慢性咽炎的疗效及对血清EGF IL-1β VCAM-1的影响

doi:10.3969/j.issn.1006-6233.2018.12.007

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Abstract Objective: To study curative efficacy of Qingkailing dripping pills in treatment of chronic pharyngitis and effects on serum epidermal growth factor (EGF), interleukin-1β (IL-1β) and Vascular endothelial cell adhesion molecule-1(VCAM-1) levels. Methods: 120 patients of chronic pharyngitis admitted to our hospital from October 2015 to October 2017 were selected as research objects, according to the simple random number table, those patients were divided into the 62 cases of observation group and the 58 cases control group, the control group was treated with conventional dexamethasone sodium phosphate+gentamicin atomization treatment, and the observation group was treated with Qingkailing dripping pills on the basis of the control group. They were treated with 1 weeks for 1 courses, and 3 consecutive courses of treatment. The clinical efficacy, the changes of serum inflammatory factors, EGF, IL-1β and VCAM-1 were compared between the two groups, and the adverse reactions and the 3 months recurrence rate were compared. Results: After treatment, the total effective rate of the observation group was 93.55% (58/62), which was significantly higher than that of the control group 79.31% (46/58) (P＜0.05); after treatment, the serum tumor necrosis factor-α (TNF-α), C reactive protein (CRP) and interleukin -6 (IL-6) in the two groups were significantly lower than those before the treatment (P＜0.05), and the serum -α, CPR and IL-6 in the observation group were significantly lower in the observation group than that of the control group [(94.52±13.89)ng/L vs(21.37±17.43)ng/L,(13.42±1.68)mg/L vs(22.30±2.93)mg/L,(110.27±14.19)ng/L vs(158.33±19.34)ng/L](P＜0.05). After treatment, the serum IL-1β in the two groups were significantly lower than those before the treatment, and the serum EGF and VCAM-1 was significantly higher (P＜0.05), and the IL-1β in the observation group were significantly lower than that of the control group, and the EGF and VCAM-1 was significantly higher than that of the control group[(82.37±8.90)pg/ml vs(114.06±12.17)pg/ml, (4.42±0.72)μg/L vs(3.37±0.68)μg/L, (8.19±1.40)ng/ml vs(5.68±1.06)ng/ml](P＜0.05). During the treatment period, the incidence of adverse reactions in the observation group and the control group was 9.68% (6/62) and 8.62% (5/58) respectively, and the difference was not statistically significant(P＞0.05). The follow-up results of 3 months follow-up showed that 2 cases relapsed in the observation group, the recurrence rate was 5.26% (2/38), and 7 cases relapsed iin the control group, the recurrence rate was 25% (7/28), and the recurrence rate of the observation group was significantly lower than that of the control group (P＜0.05). Conclusion: Qingkailingdi pills is well for chronic pharyngitis, which can effectively promote the recovery of the disease, and the recurrence rate is low in the short term. It's internal mechanism may be related to the regulation of the expression of serum EGF, IL-1β and VCAM-1, and it's highly safe and worthy of application.

Key words： Chronic pharyngitis Qingkailingdi pills Epidermal growth factor Interleukin-1β Vascular endothelial cell adhesion molecule-1

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2018.12.007 OR http://www.hbyxzzs.cn/EN/Y2018/V24/I12/1960

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