25(OH)D水平与2型糖尿病患者周围神经病变的关系

doi:10.3969/j.issn.1006-6233.2018.12.002

Abstract
Figure/Table
References
Related Citation (15)

Download: PDF (1353 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective: To analyze the relationship between the level of 25-hydroxyvitamin D [25 (OH) D] and peripheral neuropathy in patients with type 2 diabetes mellitus (T2DM). Methods: 183 cases of T2DM admitted to our hospital were selected as research object. According to whether they were accompanied by peripheral neuropathy, the group was divided into group A with peripheral neuropathy in 86 cases, group B without peripheral neuropathy in 97 cases. The differences in the level of biochemical indexes of the two groups were compared, and the factors affecting the incidence of peripheral neuropathy in patients with T2DM were analyzed by multiple factor Logistic regression, and the relationship between the clinical indexes and the occurrence of peripheral neuropathy was analyzed by Pearson correlation. Results: The serum 25 (OH) D levels in the group A was significantly lower than that of the group B, while the ages, the course of the disease, the hemoglobin A1C (HbA1c) and the homeostasis model assessment for insulin resistance index (HOMA-IR) were significantly higher than those in the group B (all P<0.05). The results of multiple factor Logistic regression analysis showed that ages, course of disease and serum level of 25 (OH) D were the main factors affecting peripheral neuropathy in patients with T2DM (all P<0.05). The Pearson correlation analysis showed that the ages, course of disease and the level of HbA1c in patients with T2DM were positively correlated with the occurrence of peripheral neuropathy, while the level of serum 25 (OH) D and HOMA-IR was negatively correlated with the occurrence of peripheral neuropathy (all P<0.05). Conclusion: There is a significant relationship between vitamin D deficiency in serum and peripheral neuropathy in patients with T2DM. Serum 25 (OH) D deficiency causes the risk of peripheral neuropathy in patients, and the risk of perinatic neuropathy is also increased with ages, course of disease and HbA1c levels.

Key words： Type 2 diabetes mellitus Peripheral neuropathy 25-hydroxyvitamin D

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	WU Yujie

Cite this article:

WU Yujie. Relationship between 25 (OH) D Level and Peripheral Neuropathy in Patients with Type 2 Diabetes Mellitus[J]. HeBei Med, 2018, 24(12): 1941-1944.

URL:

http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2018.12.002 OR http://www.hbyxzzs.cn/EN/Y2018/V24/I12/1941

[1] 杨瑞华.老年初诊2型糖尿病患者甲状腺功能与25-羟维生素D的相关性初探[J].河北医学,2018,24(5):711~714.
[2] 李蕾,张红霞,李清楚,等.运动诱发电位对2型糖尿病马尾神经近端损害的诊断价值[J].郑州大学学报(医学版),2016,51(3):401~405.
[3] Park SK, Garland CF, Gorham ED, et al. Plasma 25-hydroxyvitamin D concentration and risk of type 2 diabetes and pre-diabetes: 12-year cohort study[J]. PloS one, 2018, 13(4): e0193070.
[4] 冉亚娟,邱志茹,王少平,等.2型糖尿病神经传导异常特点[J].郑州大学学报(医学版),2014,(3):419~420,421.
[5] Zoppini G, Galletti A, Targher G, et al. Lower levels of 25-hydroxyvitamin D3 are associated with a higher prevalence of microvascular complications in patients with type 2 diabetes[J]. BMJ Open Diabetes Res Care, 2015, 3(1): e000058.
[6] Miettinen ME, Smart MC, Kinnunen L, et al. Maternal VDR variants rather than 25-hydroxyvitamin D concentration during early pregnancy are associated with type 1 diabetes in the offspring[J]. Diabetologia, 2015, 58(10): 2278~2283.
[7] 中华医学会糖尿病学分会.中国2型糖尿病防治指南(2013年版)[J].中华糖尿病杂志,2014,6(7):447~498.
[8] Yetkin DO, Kucukkaya B, Turhan M, et al. The effect of 25-hydroxyvitamin D levels on QT interval duration and dispersion in type 2 diabetic patients[J]. Croat Med, 2015, 56(6): 525~530.
[9] Ezhilarasi K, Dhamodharan U, Vijay V. BSMI single nucleotide polymorphism in vitamin D receptor gene is associated with decreased circulatory levels of serum 25-hydroxyvitamin D among micro and macrovascular complications of type 2 diabetes mellitus[J]. Int Biol Macromol, 2018, 116: 346~353.
[10] 冯菁,张兴凯,宋熔,等.维持性血液透析患者血清25-羟维生素D水平及其影响因素研究[J].河北医学,2014,20(3):405~409.
[11] Ceglia L, Nelson J, Ware J, et al. Association between body weight and composition and plasma 25-hydroxyvitamin D level in the diabetes prevention program[J]. Eur Nutr, 2017, 56(1): 161~170.
[12] 许宏亮,雷剑.2型糖尿病患者血清25-羟维生素D水平与周围神经病变的相关性研究[J].检验医学与临床,2017,14(7):936~938.
[13] Li D, Zhang Y, Li Q, et al. Low 25-hydroxyvitamin D level is associated with peripheral arterial disease in type 2 diabetes patients[J]. Arch Med Res, 2016, 47(1): 49~54.
[14] Depczynski B, Young T, White C. A high ankle-brachial index is associated with obesity and low serum 25-hydroxyvitamin D in patients with diabetes[J].Clin Transl Endocrinol, 2018, 11: 7~10.
[15] Ye Z, Sharp SJ, Burgess S, et al. Association between circulating 25-hydroxyvitamin D and incident type 2 diabetes: a mendelian randomisation study[J]. Lancet Diabetes Endocrinol, 2015, 3(1): 35~42.