|
|
|
| Effect of Aspirin combined with Clopidogrel on Oxidative Stress and Hemorheology in Patients with Cerebral Infarction |
| LI Li, WANG Qi, ZHANG Na, et al |
| Xianyang Hospital of Yan'an University, Shaanxi Yanan 712000, China |
|
|
|
|
Abstract Objective: To analyze the curative effect of aspirin combined with clopidogrel in treatment cerebral infarction and its effect on oxidative stress response and blood rheology. Methods: 106 patients with cerebral infarction were divided into 50 control group and 56 observation group according to the simple random number table. The control group was treated with aspirin, and the observation group was treated with clopidogrel on the basis of the control group. The clinical efficacy, oxidase activity, hemorheology, neurological deficit scale (NIHSS), ability of daily living (ADL), follow-up and incidence of adverse reactions were compared between the two groups. Results: The effective rate of the observation group was higher than that of the control group, and the difference was statistically significant (P<0.05). The levels of malondialdehyde (MDA) and superoxide dismutase (SOD) and catalase (CAT) in the two groups decreased 7 and 14 days after treatment, and the changes in the observation group were more significant (P<0.05). NIHSS decreased and ADL scores increased in both groups, and the changes in the observation group were more obvious (P<0.05). The plasma viscosity, whole blood viscosity and platelet aggregation rate of the two groups decreased, and the observation group was lower than the control group (P<0.05). The recurrence rate of the observation group was lower than that of the control group (P<0.05). There was no difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: Clinical curative effect of aspirin combined with clopidogrel in treatment patients with cerebral infarction is better than aspirin alone, which can reduce oxidative stress response, improve blood rheology and short-term prognosis., and do not increase adverse drug reactions.
|
|
|
|
|
|
[1] Deguchi I, Dembo T, Fukuoka T, et al. Usefulness of MRA-DWI mismatch in neuroendovascular therapy for acute cerebral infarction[J]. European Journal of Neurology, 2015, 19(1):114~120.
[2] Schins A, Hamulyák K, Scharpé S, et al. Whole blood serotonin and platelet activation in depressed post-myocardial infarction patients.[J]. Life Sciences, 2015, 76(6):637~650.
[3] 但刚,江忠勇,刘媛,等急性脑梗死血小板聚集及活化指标的变化及临床意义[J].西南国防医药,2015,25(2):124~126.
[4] 蒲应香,邢成文,李玉鹏,等.阿司匹林联合氯吡格雷治疗急性脑梗死的临床疗效[J].神经损伤与功能重建,2016,11(2):161~162.
[5] Fu P K, Pan T L, Yang C Y, et al. Carthamus tinctoriusL. ameliorates brain injury followed by cerebral ischemia-reperfusion in rats by antioxidative and anti-inflammatory mechanisms:[J]. Iranian Journal of Basic Medical Sciences, 2016, 19(12):1368~1375.
[6] 中华医学会神经病学分会.中国急性缺血性脑卒中诊治指南2014[J].中华神经科杂志,2015,48(4):246~257.
[7] Naess H, Nyland H I, Thomassen L, et al. Mild depression in young adults with cerebral infarction at long-term follow-up: a population-based study.[J]. European Journal of Neurology, 2015, 12(3):194~198.
[8] Jaremo P, Eriksson-Franzen M, Milovanovic M. Platelets, gender and acute cerebral infarction[J]. Journal of Translational Medicine, 2015, 13(1):1~4.
[9] 王利,吴常征,卞光荣,等.阿司匹林联合氯吡格雷治疗脑梗死的临床疗效[J].实用心脑肺血管病杂志,2017,25(S1):76~77.
[10] 陈燕萍,田锦勇,段畅,等.急性脑梗死患者肺部感染病原菌分布及对氧化应激反应蛋白的影响研究[J].中华医院感染学杂志,2015,25(20):4600~4601,4615. |
|
|
|
2018, Vol. 24 
