AbstractObjective: To analyze the expression of β-catenin and ILK in gallbladder carcinoma and its correlation with clinicopathologic parameters. Methods: 75 cases of cholecystitis associated with cholecystitis from April 2013 to May 2016 were selected. According to the results of pathological examination, 47 cases were gallbladder carcinoma, 13 cases were cystic polyps, and 15 cases were chronic cholecystitis. The expression levels of β-catenin and ILK were measured. Results: The expression of ILK, β -catenin in gallbladder carcinoma was significantly higher than that in cystic polyps and chronic cholecystitis (P<0.05). The positive rates of ILK and β-catenin in patients with tumor diameter ≥ 2cm were higher than those in patients with tumor diameter < 2cm, and the difference of positive rate of β -catenin was statistically significant (P<0.05). The positive rates of ILK and β -catenin in patients with different pathological differentiation degrees were significantly different. The positive rates of ILK and β -catenin from high to low were high differentiation, middle differentiation and low differentiation. The positive rate of ILK and β -catenin in serous infiltration patients was higher than that in non-serous infiltration patients (P<0.05). The positive rate of ILK and β -catenin in patients with lymph node metastasis was significantly higher than that in patients without lymph node metastasis (P<0.05). There was a significant positive correlation between the positive rate of LLK and β -catenin in gallbladder carcinoma (P<0.05). Conclusion: The positive rates of β -catenin and ILK in gallbladder carcinoma tissues are significantly increased, and the increased expression level of β -catenin and ILK may indicate the increase of invasion and lymph node metastasis risk, and the expression of β -catenin and ILK is positively correlated with the expression of β -catenin in gallbladder carcinoma.
XU Dan,et al. Expression of β-catenin and ILK in Gallbladder Carcinoma and the Correlation with Clinicopathological Parameters[J]. HeBei Med, 2018, 24(11): 1790-1793.
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2018, Vol. 24 
