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| Curative Efficacy of Esomeprazole Magnesium Enteric-coated Tablets Combined with Cisapride in the Treatment of Reflux Esophagitis |
| YUN Xiaojing, WANG Dongmei, BAI Yuhuan, et al |
| Liaocheng Second People's Hospital, Shandong Liaocheng 252600, China |
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Abstract Objective: To study the curative efficacy of Esomeprazole Magnesium Enteric-coated Tablets combined with cisapride in the treatment of reflux esophagitis. Methods: 270 cases of patients with reflux esophagitis from November 2015 to November 2016 in our hospital were selected as the research objects and randomly divided into the observation group and the control group. The control group was treated with Esomeprazole Magnesium Enteric-coated Tablets, while the observation group was treated with Esomeprazole Magnesium Enteric-coated Tablets combined cisapride. At two months after treatment, the clinical curative effect, changes of serum IL-17 and IL-23, endoscopic grading integral, and clinical symptom scores before and after treatment were compared between two groups. Results: After treatment, the total effective rate of observation group was statistically higher than that of the control group (P<0.05); After treatment, the serum IL-17,IL-23 in Observation group was less than the control group (P<0.05); After treatment ,endoscopic grading integral, clinical symptom scores in Observation group was less than the control group (P<0.05). Conclusion: Esomeprazole Magnesium Enteric-coated Tablets combined with cisapride could effectively inhibit the inflammatory response, reduce the grading score of endoscopy, relieve the clinical symptoms of patients, and thereby significantly improve its clinical efficacy.
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2018, Vol. 24 
