|
|
|
| Effect of Tongnao Decoction in Treating Acute Cerebral Infarction and Its Effect on Hemorrheology |
| ZHU Yuan, CHANG Cheng, WANG Xintong |
| Jiangsu Province Hospital of TCM, Jiangsu Nanjing 210000, China |
|
|
|
|
Abstract Objective: To investigate the clinical efficacy of Tongnao Decoction in the treatment of acute cerebral infarction (ACI) and its effect on blood circulation in patients with this disease. Methods: The randomized method was used to divide the 100 patients admitted into the group into two groups. The control group selected western medicine for routine symptomatic treatment, and the observation group took Tongnao Decoction on the basis of western medicine for routine symptomatic treatment. The changes of hemodynamics ηb, HCT, Fib, PAG, MST, serum D-D and VEGF were measured before and after treatment. The change of cerebral hemodynamic parameters MPV, DBFV, MBF, VPI and RI before and 3 months after treatment were compared between the two groups. The NHISS scores were compared between the two groups. The clinical efficacy of the two groups was statistically analyzed. Results: The cure rate (54.00%) and total effective rate (94.00%) in the observation group were significantly higher than those in the control group (30.00% and 78.00% respectively). The difference between the two groups was statistically significant (P<0.05). Analysis of variance of two-factor repeated measures showed that there were statistically significant differences in ηb, HCT, Fib, PAG, MST, MPV, DBFV, MBF, VPI and RI before and after treatment (P<0.05); There was significant difference between the control group and the observation group in ηb, HCT, Fib, PAG, MST, MPV, DBFV, MBF, VPI and RI (P<0.05). Conclusion: Tongnaoyin treatment of ACI, can effectively reduce blood viscosity, improve hemodynamics, accelerate blood circulation of brain tissue, promote the repair of nerve function in patients, the curative effect is definite.
|
|
|
|
|
|
[1] 潘双杰,何远宏,王楠,等.羟乙基淀粉对急性缺血性脑卒中患者肾功能的影响[J].郑州大学学报(医学版),2017,52(3):353~355.
[2] 刘佳,闫建齐.急性脑梗死患者血浆内皮素及血液流变学指标检测分析[J].解放军预防医学杂志,2015,33(2):187~188.
[3] 刘博,王婧.活血通络化痰方对急性脑梗死模型大鼠血液流变学指标、血浆胆红素及氧化低密度脂蛋白水平的影响[J].中国中医急症,2017,26(8):1340~1342.
[4] 韩漾,吴明华,马立,等.通脑饮对大鼠脑梗死组织血管神经再生的影响[J].吉林中医药,2013,33(11):1143~1145.
[5] 何文,肖苗,郭咸希.天麻素鼻腔原位凝胶在大鼠体内的药动学及脑靶向性研究[J].中国药师,2017,20(1):68~72.
[6] 李超,杨雯晴,王宇,等.钩藤总生物碱增强自噬降低氧化应激诱导的内皮细胞炎性反应[J].中华中医药杂志,2017,32(5):2137~2141.
[7] 彭尹宣,王兴,杨娟,等.天麻多糖对天麻钩藤药对效应成分吸收的影响[J].环球中医药,2015,8(12):1452~1454.
[8] 陆伟恒,罗成宏,廖成钜,等.尤瑞克林联合阿司匹林对急性脑梗死患者血清学指标及临床疗效的影响[J].实用医学杂志,2017,33(21):3615~3618. |
|
|
|
2018, Vol. 24 
