血浆BNP水平对老年COPD患者肺动脉高压的临床意义

doi:10.3969/j.issn.1006-6233.2018.10.011

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Abstract Objective:To investigate the clinical significance of plasma brain natriuretic peptide (BNP) level in elderly patients with chronic obstructive pulmonary disease (COPD) with pulmonary hypertension (PAH). Methods:75 aged COPD patients and 30 healthy peers who were enrolled in the hospital during the period of ~2017 in January 2017 were selected as the COPD group and the control group. According to the detection level of pulmonary artery systolic pressure (PASP), 39 cases of group COPD were not PAH (PASP < 35mmHg), and PAH group (PASP > 35mmHg) were divided into 14 cases of mild group (35mmHg < PASP < 50mmHg), 15 cases of moderate group and 10 cases of severe group. The BNP expression characteristics of COPD in the above groups were observed, and the correlation between BNP and PASP levels was analyzed. Results: The blood BNP and PASP levels in group COPD were higher than those in the control group, and the difference was statistically significant (P<0.05). The level of BNP and PASP in COPD combined with PAH group was higher than that in the non PAH group, and the difference was statistically significant (P<0.05). Linear correlation analysis and partial correlation analysis excluded gender and age factors, and there was a significant positive correlation between BNP and PASP levels (P<0.05). Conclusion: The blood BNP of the elderly COPD patients showed an abnormal rising state, and the expression was more obvious with the combination of PAH; the blood BNP and PASP levels were significantly positive correlation, which was of important guiding significance for the clinical assessment of the risk of PAH and the degree of the disease.

Key words： Chronic obstructive pulmonary disease Plasma brain natriuretic peptide Pulmonary hypertension

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2018.10.011 OR http://www.hbyxzzs.cn/EN/Y2018/V24/I10/1627

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