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| The Expression and the Clinical Significance of CDC25A and CDK1 in Gastric Cancer |
| FU Hua, YU Aijun, CHEN Kai, et al |
| The Affiliated Hospital of Chengde Medical University, Hebei Chengde 067000, China |
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Abstract Objective: To investigate the expression and the clinical significance of CDC25A and CDK1 in gastric carcinoma. Methods: Immunohistochemistry was used to detect the expression of CDC25A and CDK1 in gastric cancer tissue of 119 cases. The correlation of the expression CDC25A and CDK1 and clinical pathological characteristics were analyzed. Results: The expression of CDC25A and CDK1 in highly differentiated gastric cancer tissues was highly expressed in low differentiated gastric cancer tissues, and had significant correlation with the pathological grade of gastric cancer (P<0.001). CDC25A and CDK1 were low expression in early gastric cancer, high expression in advanced gastric cancer tissue and significant correlation with TNM staging of gastric cancer (P<0.01). The expression of CDC25A and CDK1 is significantly associated with lymph node metastasis (P<0.001) in patients with gastric cancer. CDC25A and CDK1 are highly expressed in gastric carcinoma with lymph node metastasis, and low expression in gastric cancer tissues without lymph node metastasis (P<0.001). Conclusion: CDC25 and CDK1 could be potential biomarker for diagnosis and treatment of gastric cancer.
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2018, Vol. 24 
