布地奈德雾化吸入对小儿哮喘患者外周血炎症因子及肺功能的影响

doi:10.3969/j.issn.1006-6233.2017.07.010

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Abstract Objective: To analyze aerosol inhalation of budesonide in children with clinical changes in patients with asthma and peripheral inflammatory factors and pulmonary function index. Methods: 100 cases of children with asthma admitted in our hospital from January 2015 to February 2016 were randomly divided into observation group and control group, the control group with routine intervention, the observation group in the control group on the basis of budesonide inhalation; after a week before and at the end of treatment, TNF-α in peripheral blood and IL-8, IL-4, immune immunoglobulin levels in children with asthma, were detected FEV1, FVC, PEF% records, and to evaluate the clinical symptoms in children. Results: After treatment, the symptom scores of patients of two groups were significantly reduced, and the difference was statistical significance (P<0.05); and symptom score of the patients in the observation group after treatment was significantly lower than the control group ( P<0.05); after treatment, FVC, FEV1 and PEF of two groups were significantly improved, and the difference was statistical significance (P<0.05); after treatment, the observation group with FVC, FEV1 and PEF were significantly higher than those in the control group ( P<0.05); after treatment, peripheral blood IL-4, TNF-α and IL-8 level of two groups of children were decreased, and the difference is statistical significance (P<0.05); peripheral blood IL-4, TNF-α and IL-8 level of the observation group with after treatment was significantly lower than the control group (P<0.05); after treatment, IgA and IgE were decreased significantly (P<0.05); IgG and IgM levels were significantly higher (P<0.05), statistically significant differences between the two groups of children with peripheral blood immunoglobulin level and survival after treatment (P<0.05). Conclusions: Budesonide can effectively improve the level of inflammatory factor in children with asthma in peripheral blood and improve lung function, it has high value in clinical application.

Key words： Budesonide Children with asthma Inflammation Pulmonary function

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	GUO Mei
	WANG Wei

Cite this article:

GUO Mei,WANG Wei. Budesonide Inhalation on Children with Asthma and Peripheral Inflammatory Factors and Pulmonary Function Index[J]. HeBei Med, 2017, 23(7): 1086-1090.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2017.07.010 OR http://www.hbyxzzs.cn/EN/Y2017/V23/I7/1086

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