|
|
|
| Efficacy of Los Platinum Combined Eddy Injection for Patients with Malignant Pleural Effusion |
| ZHU Yali, JI Hong, WANG Xin |
| Space Center Hospital, Beijing 100049, China |
|
|
|
|
Abstract Objective: To observe the effect of eddy injection combined los platinum pleural perfusion on advanced NSCLC patients with malignant pleural effusion and the influence on serum levels of VEGF. Methods: 74 cases of patients with malignant pleural effusion with NSCLC admitted in our hospital from April 2013 to June 2015 were divided into control group and observation group according to random parallel grouping, 37 cases in each group. The patients in the control group were treated with intrapleural perfusion of luo platinum. The patients in the observation group were treated with eddly injection on the basis of the control group. The efficacy after treatment of all the patients and its influence on serum levels of VEGF were compared. Results: After treatment, the clinical remission rate of the control group (67.5%) was significantly higher than that of the control group (48.6%) (P < 0.05). The VECR level of two groups patients(140.22±19.30ng/L vs105.54±13.48ng/L)after treatment were significantly lower than that before treatment (P < 0.05); the degree of decline in observation group was obviously higher than that of control group (P < 0.05); the incidence of patients in observation group with chest pain, bone marrow suppression was lower than that in control group (P < 0.05). Conclusion: The clinical application of los platinum pleural perfusion combined with eddy injection treatment of advanced NSCLC with malignant pleural effusion curative effect significantly, can significantly improve the serum VEGF levels, and high safety and it can be popularized in clinical application.
|
|
|
|
|
|
[1] 邝浩斌,黄冬生,吕江青,等.多西紫杉醇联合卡铂治疗晚期非小细胞肺癌的疗效观察[J].临床肺科杂志,2010,15(1):3~4.
[2] 裴文军.艾迪注射液联合GP方案对晚期非小细胞肺癌患者的疗效及对血清VEGF表达的影响[J].中国医药导报,2012,09(16):99~100.
[3] 周洋,黄河,张家洪.洛铂胸腔灌注联合艾迪注射液治疗恶性胸腔积液的临床分析及其对血清VEGF的影响[J].实用医学杂志,2014,16(10):1629~1632.
[4] 涂建仁,黄淑娟,王美鑑.重组人血管内皮抑制素联合顺铂胸腔灌注治疗晚期非小细胞肺癌恶性胸腔积液的临床疗效[J].实用癌症杂志,2014,15(12):1592~1594.
[5] 韩明辉,张清英,刘萍.艾迪注射液治疗高龄晚期肺癌恶性胸腔积液12例临床观察[J].中外健康文摘,2012,12(31):1206~1207.
[6] 朱志真,石建华,侯森.恩度联合顺铂局部治疗非小细胞肺癌合并恶性胸腔积液的疗效及对VEGF、HIF-1α的影响[J].实用癌症杂志,2014,08(7):855~857.
[7] 徐舒,马振,赵永心,等.洛铂联合伊立替康治疗复治性小细胞肺癌的临床研究[J].临床肿瘤学杂志,2010,15(7):640~642.
[8] 赵凤芝,徐萌,赵建夫.洛铂对比顺铂治疗晚期非小细胞肺癌疗效和安全性的Meta分析[J].中国药房,2014,13(36):3377~3381.
[9] 周洋,黄河,张家洪.洛铂胸腔灌注联合局部热疗治疗恶性胸腔积液的临床观察[J].现代肿瘤医学,2015,12(16):2303~2305. |
| [1] |
. [J]. 河北医学, 2017, 23(6): 1014-1016. |
|
|
|
|
2017, Vol. 23 
