AbstractObjective: To analyze the expression of EGFR, c-Met and Ki-67 in gastric cancer with intravascular cancer embolus and their influence on the prognosis. Methods: The expression of EGFR, c-Met and Ki-67 in 88 gastric cancer cases and 39 cases of intravascular cancer embolus were detected and the difference between 1-year and 3-year survival rate in cancer embolus positive and negative patients group were analyzed. Results: In gastric cancer tissue with intravascular cancer embolus, the strong positive expression rates of EGFR, c-Met and Ki-67 were all higher than those in gastric cancer tissue without intravascular cancer embolus (P<0.05). The strong positive expression rates of EGFR, c-Met and Ki-67 in gastric cancer tissue without intravascular cancer embolus 1-year and 3-year survival rate were obviously higher than those of cancer embolus positive group (P<0.05). Conclusions: The expression and prognosis of EGFR, c-Met and Ki-67 are related to the gastric cancer with intravascular cancer embolus, and has rather poor prognostic significance in gastric cancer.
[1] 陈万青,张思维,曾红梅,等.中国2010年恶性肿瘤发病与死亡[J].中国肿瘤,2014,23(1):1~10. [2] Du Cy, Chen J G, Zhou Y, et al. Impact of lymphatic and /or blood vessel invasion in stage Ⅱ gastric cancer[J].World Gastroenterol, 2012, 18(27):3610~3616. [3] 刘文峰,犹东,郭鑫,等.胃癌EGFR与C~erbB~2基因表达的临床意义[J].宁夏医学杂志,2010,32(9):774~776. [4] Lee HE, Kim MA, Lee BL, Kim WH. Low Ki67 proliferation index is an indicator of poor prognosis in gastric cancer[J].Surg Oncol 2010, 102(3) :201~206. [5] Gao M, Liang X J, Zhang Z S, et a1. Relationship between expression of EGFR in gastric cancer tissue and clinicopathological features[J].Asian Pac Trop Med, 2013, 6(4) :260~264. [6] Rousselet E, Traver S, Monnet Y, et a1. Turmor necrosis factor-like weak inducer of apoptosis induces astrocyte proliferation through the activation of transforming~growth factor~alpha/ epidermal growth factor receptor signaling pathway[J].Mol Pharmacol, 2012, 82(5) :948~957. [7] Tampellini M, Longo M, Cappia S, et a1. Co-expression of EGF receptor. TG Falpha and S6 kinase is significantly associated with colorectal carcinomas with distant metastases at diagnosis[J].Virchows Arch, 2007, 450(3) : 321~328. [8] Yarden Y,Sliwkowski M X. Untangling the ErbB signaling network[J].Nat Rev Mol Cell Biol, 2001, 2(2) :127~137. [9] BIRCHMEIERC, BIRCHMEIERW, GHERARDIE, et al. Met, metastasis, motility and more[J].Nat Rev Mol Cell Biol, 2003, 4(12) :915~925. [10] BLUMENSCHEIN GR J R, MILLS G B, GONZALEZ ANGULO A M. Targeting the hepatocyte growth factor~cMET axis in caner theapy[J].Clin Oncol, 2012, 30 (26) :3287~3296.
2017, Vol. 23 
