粒细胞集落刺激因子治疗缺血性脑卒中的临床分析

doi:10.3969/j.issn.1006-6233.2017.12.010

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Abstract Objective: To investigate the value of granulocyte colony-stimulating factor (G-CSF) in the treatment of patients with ischemic stroke and the effect on neurological function. Methods: A total of 120 patients with ischemic stroke were selected as study subjects. By the random number table method, they were divided into study group and control group, 60 cases in each group. The control group (60 cases, 56 cases completed, 4 cases lost to follow up) was treated with conventional symptomatic treatment (thrombolysis, anticoagulation, improving cerebral circulation, lowering intracranial pressure, oxygen inhalation, anti-infection, oxygen inhalation, anti-encephaledema, cerebral protection, etc.); the study group (60 cases, 54 cases completed, 6 cases lost to follow up), was treated combined with recombinant human G-CSF injection [2μg/(kg·d), iH, for 5d], based on the treatment in the control group; curative effect in both groups was observed after 12 weeks of treatment. Changes of serum neuron specific enolase (NSE), neuropeptide Y (NPY), serum nuclear factor kappa B (NF-κB) and inflammatory factors [interleukin - 6 (IL-6), tumor necrosis factor alpha (TNF-α)] before and after treatment were compared between the two groups. The incidence of adverse reactions was recorded, and the differences in neurological function recovery before and after treatment were analyzed. Results: After 5d and 12 weeks of treatment, the test results of serum NSE, NPY, NF-κB, serum IL-6, TNF-a and other inflammatory cytokines and NFDS scores in both groups were significantly lower than those before treatment, and the study group was lower than the control group (P < 0.05). There were no serious adverse reactions in both groups, and there were no significant differences in the incidence rates of mild anorexia, nausea, muscular soreness, rash and other adverse reactions between the two groups (P > 0.05). Conclusion: G-CSF can effectively promote the recovery of neurological function in patients with ischemic stroke, and the anti-inflammation effect is ideal, which is beneficial to the prognosis of patients.

Key words： Granulocyte colony stimulating factor Ischemic stroke NSE NPY

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	LI Yuyang
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LI Yuyang,et al. Clinical Analysis of Granulocyte Colony-stimulating Factor in the Treatment of Ischemic Stroke[J]. HeBei Med, 2017, 23(12): 1970-1973.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2017.12.010 OR http://www.hbyxzzs.cn/EN/Y2017/V23/I12/1970

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