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Correlation Study of Platelet Parameters NF-κB IL-6 Levels with Disease Severity and Prognosis in Patients with Cirrhosis Complicated by Upper Gastrointestinal Bleeding |
CAI Xu, XU Shuai, SHANG Shuai |
No. 902 Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army, Anhui Bengbu 233000, China |
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Abstract Objective: To analyze the correlation between platelet parameters, serum nuclear factor-κB (NF-κB), interleukin-6 (IL-6) levels, and the disease severity and prognosis in patients with cirrhosis complicated by upper gastrointestinal bleeding (UGIB).Methods: A total of 155 patients with cirrhosis complicated by UGIB, treated at our hospital from January 2021 to January 2024, were included in the study. Based on the amount of blood loss before admission, they were divided into a mild group (n=70) and a moderate to severe group (n=85). Additionally, based on the prognosis, they were categorized into a good prognosis group (n=122) and a poor prognosis group (n=33). Platelet parameters [platelet count (PLT), mean platelet volume (MPV), plateletcrit (PCT), platelet distribution width (PDW)], serum NF-κB, and IL-6 levels were measured in all patients. Spearman rank correlation analysis was used to evaluate the relationship between these parameters and the severity and prognosis of cirrhosis complicated by UGIB.Results: The PLT, MPV, PCT, PDW, serum NF-κB, and IL-6 levels in the moderate to severe group were significantly higher than those in the mild group (P<0.05). Similarly, these parameters were higher in the poor prognosis group compared to the good prognosis group (P<0.05). Spearman rank correlation analysis indicated a positive correlation between PLT, MPV, PCT, PDW, serum NF-κB, IL-6 levels, and the severity of cirrhosis complicated by UGIB (r=0.226,0.311,0.387,0.311,0.351,0.386; P<0.05).Conclusion: Platelet parameters, NF-κB, and IL-6 levels are closely related to the severity and prognosis of patients with cirrhosis complicated by UGIB. Early detection of these serum indicators can provide a reference for clinical assessment of disease severity and prognosis.
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[1] Targownik LE,Fisher DA,Saini SD.AGA clinical practice update on de-prescribing of proton pump inhibitors:expert review[J].Gastroenterology,2022,162(4):1334-1342.
[2] Kruger AJ,Abougergi MS,Jalil S,et al.Outcomes of nonvariceal upper gastrointestinal bleeding in patients with cirrhosis:a national analysis[J].Clin Gastroenterol,2023,57(8):848-853.
[3] Tatliparmak AC,Dikme O,Dikme O,et al.Cancer,platelet distribution width,and total protein levels as predictors of rebleeding in upper gastrointestinal bleeding[J].Peer,2022(10):14061.
[4] 唐闯,张鑫,张婷.艾司奥美拉唑镁联合白眉蛇毒血凝酶对非静脉曲张性上消化道出血的治疗效果观察[J].上海交通大学学报(医学版),2022,42(11):1576-1581.
[5] 陈峥,彭亚文,孙虹雨.核因子-κB信号通路相关因子在急性上消化道出血患者中的表达及相互关系[J].中国医刊,2023,58(7):714-718.
[6] 中华医学会肝病学分会.肝硬化诊治指南[J].中华肝脏病杂志,2019,27(11):846-865.
[7] 中国医师协会急诊医师分会,中华医学会急诊医学分会,全军急救医学专业委员会,中国急诊专科医联体,北京急诊医学学会.急性上消化道出血急诊诊治流程专家共识(2020版)[J].中华急诊医学杂志,2021,30(1):15-24.
[8] Fouad TR,Abdelsameea E,Abdel-Razek W,et al.Upper gastrointestinal bleeding in Egyptian patients with cirrhosis:post-therapeutic outcome and prognostic indicators[J].Gastroenterol Hepatol,2019,34(9):1604-1610.
[9] 张宁,谢元元.肝硬化患者血小板参数、门静脉宽度及凝血功能与上消化道出血关系的相关探讨[J].血栓与止血学,2021,27(5):801-802.
[10] Ding Y,Chen Q.The NF-κB pathway:a focus on inflammatory responses in spinal cord injury[J].Mol Neurobiol,2023,60(9):5292-5308.
[11] Duan Y,Chen J,Cui H,et al.The effect of pantoprazole and somatostatin combined with thrombin in the treatment of non-esophagogastric varicosity upper gastrointestinal bleeding[J].Am Transl Res,2021,13(5):5484-5490.
[12] 范子玲,辛克锋.凝血指标与血小板参数在肝硬化门静脉高压患者消化道出血中预测价值研究[J].临床军医杂志,2019,47(9):936-937.
[13] 苏小红,李静博.肝硬化患者血小板参数、凝血指标与上消化道出血的相关性[J].肝脏,2023,28(10):1171-1174. |
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