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| Correlation of Serum ICAM-1 Hcy and MCP-1 Levels with Vascular Endothelial Function in Patients with Retinal Vein Occlusion |
| ZHENG Bo, CHEN Lili |
| Xi'an First Hospital, Shaanxi Xi'an 710002, China |
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Abstract Objective: To investigate the correlation between serum intercellular adhesion molecule-1 (ICAM-1), Homocysteine (Hcy), and Monocyte chemotactic protein-1 (MCP-1) levels and vascular endothelial function in patients with retinal vein occlusion (RVO).Methods: A retrospective, double-blind method was used to analyze 95 patients with RVO admitted to our hospital from July 2020 to October 2023 as the RVO group, and 102 healthy people who underwent a physical examination in our hospital during the same period were selected as the normal control group. To compare the levels of ICAM-1, Hcy, MCP-1, vascular endothelial function [Endothelin-1 (ET-1), nitric oxide (NO)] between the two groups; to compare the levels of ICAM-1, Hcy, MCP-1, ET-1 and NO in the RVO group with different types of diseases; to compare the levels of ICAM-1, MCP-1, ET-1 and NO in the RVO group with different degrees of diseases; and to analyze the correlation between serum levels of ICAM-1, Hcy, MCP-1 and vascular endothelial function in RVO patients.Results: Serum ICAM-1, Hcy, MCP-1, and ET-1 levels were higher and NO levels were lower in the RVO group than in the control group (P<0.05); serum ICAM-1, Hcy, MCP-1, and ET-1 levels were higher and NO levels were lower in the CRVO patients than in the BRVO patients (P<0.05); ICAM-1, MCP-1, and ET 1levels: mild<moderate<severe, NO levels: mild>moderate>severe (P<0.05); serum ICAM-1, Hcy, MCP-1 levels were positively correlated with ET-1 levels and negatively correlated with NO levels (P<0.05).Conclusion: Serum ICAM-1, Hcy and MCP-1 levels are all abnormally elevated in RVO patients, and are correlated with ET-1 and NO to a certain extent. Detection of serum ICAM-1, Hcy and MCP-1 levels can be used to assess the status of vascular endothelial function injury, to facilitate early treatment.
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2024, Vol. 30 
