|
|
|
| Effects of Compound Matrine Injection Combined with Xihuang Pill on Cancer Pain and Fatigue Median Survival and Complication Rate in Patients with Advanced Colorectal Cancer Undergoing Palliative Care |
| FAN Yongqiang, XU Yufeng, CHEN Lin |
| The First Affiliated Hospital of Chengdu Medical College, Sichuan Chengdu 610500, China |
|
|
|
|
Abstract Objective: To investigate the effects of compound Kushin injection combined with Xihuang Pill on cancer pain and fatigue, median survival and complication rate in patients with advanced colorectal cancer receiving palliative care. Methods: A total of 153 patients with advanced colorectal cancer treated in The First Affiliated Hospital of Chengdu Medical College from January 2020 to May 2021 were randomly divided into control group (conventional palliative care), monotherapy group (conventional palliative care + Xihuang pill) and combination group (conventional palliative care + Xihuang pill + compound matrine injection), with 51 cases in each group. Cancer pain [numerical pain scale (NRS)], cancer fatigue [Piper Revised Fatigue Scale (PFS-R)], survival [Functional status score (KPS)], inflammatory factors [interleukin-6 (IL-6), C-reactive protein (CRP), and IL-8, IL-1β], immune function (total T lymphocytes, total B lymphocytes, NK cells) were compared between the 3 groups before treatment, 1 cycle and 3 cycles after treatment, and the tumor control effect, complications, toxicity and median survival of the 3 groups were compared. Results: The proportion of stable tumor in combination group was higher than that in control group and monotherapy group, and the proportion of progressive patients was lower than that in monotherapy group and control group, and the proportion of patients in monotherapy group was lower than that in control group (P<0.05). After 1 and 3 cycles of treatment, the NRS score and PFS-R score in combination group were lower than those in monotherapy group and control group, and the monotherapy group was lower than that in control group, and the KPS score was higher than that in monotherapy group and control group, and the monotherapy group was higher than that in control group (P<0.05). After 1 and 3 cycles of treatment, the total T lymphocytes, total B lymphocytes and NK cells in combination group were higher than those in monotherapy group and control group, and monotherapy group was higher than control group (P<0.05). The levels of IL-6, CRP, IL-8 and IL-1β in combination group were lower than those in monotherapy group and control group after 1 and 3 cycles of treatment, and those in monotherapy group were lower than those in control group (P<0.05). The incidence of constipation, insomnia, intestinal obstruction, intestinal bleeding, hypothermia and infection in combination group was lower than that in monotherapy group and control group, and the incidence of constipation, insomnia, intestinal obstruction, hypothermia and infection in drug group was lower than that in control group (P<0.05). The incidence of nausea, vomiting and myelosuppression in combination group was lower than that in monotherapy group and control group, and the incidence in monotherapy group was lower than that in control group (P<0.05). After 2 years of follow-up, 2 cases were lost to follow-up, 7 cases died in the combination group, 20 cases died in the monotherapy group, and 34 cases died in the control group. The median survival time of combination group, single drug group and control group was 18, 14 and 13 months, respectively, and the median survival time of combination group was longer than that of monotherapy group and control group (P<0.05). Conclusion: Compound matrine injection combined with Xihuang Pill effectively alleviated cancer pain and fatigue, improve the quality of life, enhance immune function, reduce inflammatory response and complication rate in patients with advanced colorectal cancer in palliative care.
|
|
|
|
|
|
[1] Cao W,Chen HD,Yu YW,et al.Changing profiles of cancer burden worldwide and in China:a secondary analysis of the global cancer statistics 2020[J].Chin Med (Engl),2021,134(7):783-791.
[2] Baidoun F,Elshiwy K,Elkeraie Y,et al.Colorectal cancer epidemiology:recent trends and impact on outcomes[J].Curr Drug Targets,2021,22(9):998-1009.
[3] Biller LH,Schrag D.Diagnosis and treatment of metastatic colorectal cancer:a review[J].JAMA,2021,325(7):669-685.
[4] Cervantes A,Adam R,Rosello S,et al.Electronic address:clinicalguidelines@esmo.org.Metastatic colorectal cancer:ESMO Clinical Practice Guideline for diagnosis,treatment and follow-up[J].Ann Oncol,2023,34(1):10-32.
[5] 赵小鹏,乔树斌,刘璇,等.西黄丸联合针灸对非小细胞肺癌免疫功能及生命质量的影响[J].世界中医药,2022,17(14):2021-2025.
[6] 国家卫生健康委员会医政司,中华医学会肿瘤学分会.国家卫生健康委员会中国结直肠癌诊疗规范(2023版)[J].中华普通外科杂志,2023,38(8):561-581.
[7] 孔宪斌,杨振弢,彭莹莹,等.基于“虚、毒、瘀”浅谈结直肠癌的病机和治疗[J].环球中医药,2020,13(12):2081-2084.
[8] Xu XC,Zhang JM,Zhang ZH,et al.Systems pharmacology in combination with proteomics reveals underlying mechanisms of Xihuang pill against triple-negative breast cancer[J].Bioengineered,2020,11(1):1170-1188.
[9] Wang JW,Hou DR,Peng YH,et al.Efficacy and safety of Xihuang pill for gastric cancer:a protocol for systematic review and meta-analysis[J].Medicine (Baltimore),2021,100(19):25726.
[10] 王强.复方苦参注射液联合化疗治疗卵巢癌疗效和安全性的meta分析[D].吉林:长春中医药大学,2021.
[11] Jhunjhunwala S,Hammer C,Delamarre L.Antigen presentation in cancer:insights into tumour immunogenicity and immune evasion[J].Nat Rev Cancer,2021,21(5):298-312.
[12] 郭玮,马志强,帅丙帅.西黄丸联合复方苦参注射液对乳腺癌术后化疗患者的疗效[J].河南医学研究,2023,32(16):3014-3018.
[13] 许文婧,马玥诗,王佩,等.复方苦参注射液通过保护线粒体防治大鼠急性放射性皮炎的研究[J].中医药信息,2022,39(6):6-11. |
|
|
|
2024, Vol. 30 
