孕妇外周血miR-152 miR-210与子痫前期病情程度及妊娠结局的相关性研究

doi:10.3969/j.issn.1006-6233.2024.05.027

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Abstract Objective: To investigate the correlation between the expression levels of microRNA-152 (miR-152) and miR-210 in peripheral blood of pregnant women and the severity of preeclampsia (PE) and pregnancy outcomes. Methods: A total of 200 patients with PE admitted to our hospital from July 2018 to May 2022 were selected. According to the severity of the disease, they were divided into the mild group (mild PE patients, n=114) and the severe group (severe PE patients, n=86). Another 100 healthy pregnant women of the same age were selected as the control group. The blood pressure [systolic blood pressure (SBP), diastolic blood pressure (DBP)], 24-hour urine protein quantitative (24 h Upro), calcium ion (Ca⁺), and peripheral blood miR-152 and miR-210 levels in the three groups were compared. The correlation between peripheral blood miR-152 and miR-210 levels and PE severity, blood pressure, 24 h Upro, and Ca⁺ was analyzed. The PE patients were followed up until the end of pregnancy, and the clinical data, peripheral blood miR-152, and miR-210 levels of PE patients with different pregnancy outcomes were compared. Lasso regression and Logistic regression were used to analyze the correlation between the predictive factors and adverse pregnancy outcomes. The receiver operating characteristic curve (ROC) and clinical decision curve (DCA) were used to evaluate the value and clinical utility of peripheral blood miR-152 and miR-210 in predicting adverse pregnancy outcomes in PE patients. Results: There were statistically significant differences in SBP, DBP, 24 h Upro, peripheral blood miR-152, and miR-210 levels among the severe group, mild group, and control group (P<0.05). The peripheral blood miR-152 and miR-210 levels were positively correlated with the severity of PE, blood pressure, and 24 h Upro (P<0.05), and negatively correlated with Ca⁺ level (P<0.05). The age, abortion history, severity, SBP, DBP, 24 h Upro, Ca⁺, and peripheral blood miR-152 and miR-210 levels of patients with adverse pregnancy outcomes were compared with those of patients without adverse pregnancy outcomes, and the differences were statistically significant (P<0.05). Lasso regression selected five predictive variables: severity, SBP, 24 h Upro, and peripheral blood miR-152 and miR-210 levels. Logistic regression showed that peripheral blood miR-152 and miR-210 levels were independent risk factors for adverse pregnancy outcomes in PE patients (P<0.05). The ROC and DCA results showed that the combination of peripheral blood miR-152 and miR-210 had good predictive value and clinical utility in predicting adverse pregnancy outcomes in PE patients. Conclusion: The expression of peripheral blood miR-152 and miR-210 is up-regulated in PE patients, and it is significantly correlated with the severity of the disease and pregnancy outcomes. The combination of the two has a certain reference value and clinical utility for predicting adverse pregnancy outcomes in patients.

Key words： Peripheral blood miR-152 miR-210 Preeclampsia Severity Pregnancy outcome

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	ZHAO Zeyan
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ZHAO Zeyan,et al. Correlation of miR-152 and miR-210 in Peripheral Blood of Pregnant Women with the Extent of Pre-eclampsia and Pregnancy Outcome[J]. HeBei Med, 2024, 30(5): 849-856.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2024.05.027 OR http://www.hbyxzzs.cn/EN/Y2024/V30/I5/849

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