|
|
Application of CO2 Fractional Laser Pretreatment Combined with Photodynamic Therapy in Patients with Facial Flat Warts |
JIANG Chongjing, LIU Rongrong |
The First Affiliated Hospital of Air Force Military Medical University, Shaanxi Xi'an 710032, China |
|
|
Abstract Objective: To investigate the efficacy of CO2 fractional laser pretreatment combined with photodynamic therapy in patients with facial flat warts. Methods: A total of 109 patients with facial flat warts who visited our hospital from May 2020 to March 2023 were randomly divided into a control group (55 cases, 2 cases were excluded, and 53 cases were finally completed) and an observation group (54 cases, 1 case was excluded, and 53 cases were finally completed) using a random number table method. The control group was treated with photodynamic therapy alone, and the observation group was treated with photodynamic therapy after CO2 fractional laser pretreatment. The total effective rate and recurrence rate at 6 months follow-up were compared between the two groups. The changes in inflammatory factors [interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and interferon-γ (INF-γ)] and lesion symptom scores before and after treatment were observed in the two groups. Results: The overall efficacy of the observation group was higher than that of the control group (P<0.05). There was no difference in inflammatory factors between the two groups before treatment (P>0.05). The inflammatory factors decreased after treatment in both groups, and the difference in inflammatory factors before and after treatment in the observation group was greater than that in the control group (P<0.05). There was no difference in lesion symptom scores between the two groups before treatment. The number, size, color, thickness, itching degree, and isomorphic reaction scores of lesions decreased after treatment in both groups, and the difference in lesion symptom scores before and after treatment in the observation group was greater than that in the control group (P<0.05). After 6 months of follow-up, the recurrence rate in the observation group was 3.701% (1/27 cases) compared with 25.00% (4/16 cases) in the control group, which was not statistically significant (P>0.05). Conclusion: CO2 fractional laser pretreatment combined with photodynamic therapy can reduce inflammatory response, alleviate symptoms, and improve the efficacy in patients with facial flat warts.
|
|
|
|
|
[1] Quintana Castanedo L,Tarin Vicente E,Nuno Gonzalez A,et al.Treatment of recalcitrant facial flat warts with ingenol mebutate gel with excellent results[J].Journal of Cosmetic Dermatology,2022,21(3):1305-1307. [2] 中华医学会,中华医学会杂志社,中华医学会皮肤性病学分会,等.病毒疣基层诊疗指南(2022年)[J].中华全科医师杂志,2022,21(10):904-913. [3] Zhu P,Qi R Q,Yang Y,et al.Clinical guideline for the diagnosis and treatment of cutaneous warts (2022)[J].Journal of evidence-based medicine,2022,15(3):284-301. [4] 陈晓萱,付希安,岳振华,等.光动力联合CO2点阵激光治疗播散型扁平疣3例[J].中国麻风皮肤病杂志,2023,39(4):261-264. [5] 赵辨.中国临床皮肤病学[M].第4 版.南京:江苏科学技术出版社,2010.236-240. [6] 张学军,郑捷.皮肤性病学[M].第9 版.北京:人民卫生出版社,2018.70-72. [7] Jain M,Yadav D,Jarouliya U,et al.Epidemiology,molecular pathogenesis,immuno-pathogenesis,immune escape mechanisms and vaccine evaluation for HPV-associated carcinogenesis[J].Pathogens,2023,12(12):1380. [8] 袁丹,许兰,陈华全.CO2点阵激光联合光动力疗法治疗28例面部扁平疣疗效观察[J].医学美学美容,2020,29(5):2-3. [9] 陈沁,葛兰.2种不同预处理联合5-氨基酮戊酸光动力疗法治疗面部泛发性扁平疣的疗效比较[J].中国中西医结合皮肤性病学杂志,2021,20(6):612-614. |
|
|
|