肺保护通气策略对慢性阻塞性肺疾病模型呼吸功能和血液动力学的影响

doi:10.3969/j.issn.1006-6233.2024.05.015

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Abstract Objective: To investigate the effects of different tidal volumes and positive end-expiratory pressure (PEEP) lung protective ventilation strategies on respiratory function and hemodynamics in COPD rat models. Methods: COPD rat models were established by smoke inhalation and intratracheal administration of lipopolysaccharide (LPS). Rats were randomly divided into 9 groups (10 rats per group): control and COPD groups received tracheal intubation only without mechanical ventilation; L+P0 group, L+P3 group, L+P5 group, and L+P10 group received mechanical ventilation with 6 ml/kg tidal volume and 0 cm H₂O, 3 cm H₂O, 5 cm H₂O, and 10 cm H₂O PEEP, respectively, for 120 min after tracheal intubation; H+P0 group, H+P3 group, H+P5 group, and H+P10 group received mechanical ventilation with 20 ml/kg tidal volume and 0 cm H₂O, 3 cm H₂O, 5 cm H₂O, and 10 cm H₂O PEEP, respectively, for 120 min after tracheal intubation. Respiratory function and hemodynamic parameters were measured using a small animal non-invasive respiratory function monitoring system and blood gas analyzer. Enzyme-linked immunosorbent assay (ELISA) was used to detect the levels of inflammatory mediators in lung tissue and bronchoalveolar lavage fluid (BALF). Results: Compared with the control group, COPD rats showed significantly decreased respiratory function parameters and PaO₂ (P<0.05); compared with the COPD group, L+P0 group, L+P3 group, and L+P5 group showed significantly increased respiratory function parameters and PaO₂ (P<0.05), while L+P10 group, H+P0 group, H+P3 group, H+P5 group, and H+P10 group showed significantly decreased respiratory function parameters and PaO₂ (P<0.05); L+P5 group showed significantly higher respiratory function parameters and PaO₂ than L+P0 group and L+P3 group (P<0.05); compared with L+P5 group, L+P10 group, H+P0 group, H+P3 group, H+P5 group, and H+P10 group showed significantly decreased respiratory function parameters and PaO₂ (P<0.05). Compared with the control group, COPD rats showed significantly increased levels of IL-8 and TNF-α in lung tissue and BALF, while IL-10 levels were significantly decreased (P<0.05); compared with the COPD group, L+P0 group, L+P3 group, and L+P5 group showed significantly decreased levels of IL-8 and TNF-α and significantly increased levels of IL-10 (P<0.05), while L+P10 group, H+P0 group, H+P3 group, H+P5 group, and H+P10 group showed significantly increased levels of IL-8 and TNF-α and significantly decreased levels of IL-10 (P<0.05); L+P5 group showed significantly lower levels of IL-8 and TNF-α in lung tissue and significantly higher levels of IL-10 than L+P0 group and L+P3 group (P<0.05); compared with L+P5 group, L+P10 group, H+P0 group, H+P3 group, H+P5 group, and H+P10 group showed significantly increased levels of IL-8 and TNF-α and significantly decreased levels of IL-10 (P<0.05). Conclusion: Lung protective ventilation strategies with low tidal volume and higher PEEP (such as 5 cm H₂O PEEP) can alleviate lung inflammation and lung injury in COPD rats, improve respiratory function and hemodynamics in COPD patients.

Key words： Lung protective ventilation strategy Chronic obstructive pulmonary disease Respiratory function Hemodynamics Inflammatory response

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	XIE Xiang
	WANG Yan
	CAO Dongming

Cite this article:

XIE Xiang,WANG Yan,CAO Dongming. Effect of Lung Protective Ventilation Strategies on Respiratory Function and Hemodynamics in Chronic Obstructive Pulmonary Disease (COPD) Rats[J]. HeBei Med, 2024, 30(5): 787-793.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2024.05.015 OR http://www.hbyxzzs.cn/EN/Y2024/V30/I5/787

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