癫痫患者脑电图异常和血清BDNF GFAP miR-7-5p表达特征及与认知功能的关系

doi:10.3969/j.issn.1006-6233.2024.04.018

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Abstract Objective: To explore the relationship between EEG abnormalities, serum levels of Brain-Derived Neurotrophic Factor (BDNF), Glial Fibrillary Acidic Protein (GFAP), and miR-7-5p expression characteristics, and cognitive function in epilepsy patients. Methods: The study included 294 epilepsy patients treated at our hospital from April 2017 to April 2021. Cognitive function was assessed using the Montreal Cognitive Assessment (MoCA) scale. Patients were divided into two groups based on their MoCA scores: 198 patients with scores ≥26 were included in the cognitively normal group, while 96 patients with scores <26 were included in the cognitive impairment group. All patients underwent EEG examinations. The study compared EEG abnormalities and serum levels of BDNF, GFAP, and miR-7-5p between the groups and investigated their association with cognitive impairment. Results: Analysis of the MoCA scores showed that patients in the cognitive impairment group had significantly lower scores than those in the cognitively normal group (P<0.05). Compared to the cognitively normal group, patients in the cognitive impairment group had a lower proportion of normal EEGs and higher rates of epileptiform discharges and slow-wave activity (P<0.05). Serum levels of BDNF and miR-7-5p were lower, while GFAP levels were higher in the cognitive impairment group (P<0.05). Pearson correlation analysis indicated that cognitive function in epilepsy patients was positively correlated with BDNF and miR-7-5p levels and negatively correlated with GFAP levels (P<0.05). ROC curve analysis demonstrated that BDNF, miR-7-5p, and GFAP levels have diagnostic value for cognitive impairment in epilepsy patients, with AUC values of 0.836, 0.845, and 0.957, respectively. Conclusion: The abnormal characteristics of EEG in patients with cognitive impairment are mainly EEG discharge and slow wave distribution of EEG. The expression of serum BDNF and miR-7-5p is lower than that of patients with normal epilepsy, and the expression of GFAP is higher than that of patients with normal epilepsy, and serum BDNF, miR-7-5p and GFAP have certain diagnostic value for the occurrence of cognitive impairment in patients with epilepsy.

Key words： Epilepsy EEG abnormalities Cognitive impairment Brain-derived neurotrophic factor Glial fibrillary acidic protein miR-7-5p

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	BAI Yang
	YANG Yue
	QI Huizhen

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BAI Yang,YANG Yue,QI Huizhen. The Relationship Between EEG Abnormalities and Serum BDNF GFAP miR-7-5p Expression Characteristics and Cognitive Function in Epilepsy Patients[J]. HeBei Med, 2024, 30(4): 623-629.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2024.04.018 OR http://www.hbyxzzs.cn/EN/Y2024/V30/I4/623

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