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| Analysis of Factors Influencing Early Neurological Deterioration after Emergency Interventional Thrombolysis in Patients with Acute Cerebral Infarction |
| ZHANG Feng, JI Liu, GE Chunyang, et al |
| Hefei Second People's Hospital, Anhui Hefei 230011, China |
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Abstract Objective: To investigate the factors influencing early neurological deterioration (END) after emergency interventional thrombolysis in patients with acute cerebral infarction. Methods: A total of 105 patients with acute cerebral infarction who underwent emergency interventional thrombolysis in our hospital from March 2020 to March 2023 were enrolled in this study. According to whether END occurred within 24 hours after thrombolysis, the patients were divided into the END group (n=34) and the non-END group (n=71). Univariate analysis was used to analyze the factors related to END, and multivariate logistic regression analysis was used to analyze the independent risk factors for END. Results: Univariate analysis showed no significant differences between the END and non-END groups in terms of gender, age, BMI, smoking history, drinking history, hypertension history, diabetes history, coronary heart disease history, and distribution of the responsible large vessel (P>0.05). However, the degree of stenosis of the responsible large vessel was significantly different between the END and non-END groups (P<0.05). Univariate analysis of the quantitative data showed that the National Institutes of Health Stroke Scale (NIHSS) score, thrombolysis time, white blood cell count, neutrophil count, Lp-PLA2 level, and lipoprotein a level were significantly different between the END and non-END groups (P<0.05). However, there were no significant differences between the END and non-END groups in terms of time from onset to thrombolysis, D-dimer level, and Hcy level (P>0.05). Multivariate logistic regression analysis showed that the degree of stenosis of the responsible large vessel, NIHSS score on admission, thrombolysis time, white blood cell count, neutrophil count, Lp-PLA2, and lipoprotein a were independent risk factors for END. Conclusion: The incidence of END after emergency interventional thrombolysis in patients with acute cerebral infarction is high and is influenced by multiple factors. The degree of stenosis of the responsible large vessel, NIHSS score on admission, thrombolysis time, white blood cell count, neutrophil count, Lp-PLA2, and lipoprotein a are independent risk factors for END.
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2024, Vol. 30 
