替格瑞洛联合PCI治疗老年急性心肌梗死对患者氧化应激损伤心功能及不良心血管事件发生的影响

doi:10.3969/j.issn.1006-6233.2024.04.011

Abstract
Figure/Table
References
Related Citation (15)

Download: PDF (1250 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective: To observe the effects of Ticagrelor combined with percutaneous coronary intervention (PCI) on oxidative stress injury, cardiac function and adverse cardiovascular events in elderly patients with acute myocardial infarction. Methods: A total of 160 elderly patients with acute myocardial infarction who underwent PCI treatment in our hospital from January 2020 to June 2021 were selected as the study subjects. They were randomly divided into two groups using a random number table method, with a single group of 80 patients. Both groups received PCI treatment, the control group received dual antiplatelet therapy of aspirin combined with clopidogrel, and the observation group received antiplatelet therapy of aspirin combined with tigrel. Compare the differences in cardiac function, oxidative stress injury, high sensitivity C-reactive protein (hs CRP), soluble CD40 ligand (sCD40L), N-terminal proBNP precursor (NT-proBNP), and activated platelet glycosylation complex (PAC-1) between the two groups, and analyze the occurrence of major adverse cardiovascular events (MACE) between the two groups. Results: Before treatment, there was no statistically significant difference in cardiac function between the two groups (P>0.05). Compared with before treatment, the left ventricular ejection fraction (LVEF), stroke volume (SV), and cardiac index (CI) of the two groups increased at 4 and 24 weeks of treatment. There was no statistically significant difference in cardiac function between the two groups (P>0.05). Before treatment, there was no statistically significant difference in the indicators of oxidative stress damage, hs CRP, NT-proBNP, sCD40L, and PAC-1 between the two groups (P>0.05). Compared with before treatment, hs CRP, NT-proBNP, malondialdehyde (MDA), sCD40L, and PAC-1 in both groups decreased at 4 and 24 weeks of treatment. The observation group was lower than the control group at 4 and 24 weeks of treatment (P<0.05), and the levels of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in both groups increased at 4 and 24 weeks of treatment. The observation group was higher than the control group at 4 and 24 weeks of treatment (P<0.05). The incidence of MACE in the observation group was 7.50% (6/80), lower than the control group's 18.75% (15/80) (P<0.05), and the cumulative incidence of adverse reactions was 13.75% (11/80). There was no statistically significant difference (P>0.05) compared to the control group's 11.25% (9/80). Conclusion: Tiagrelor combined with PCI in the treatment of elderly patients with acute myocardial infarction can reduce oxidative stress injury, reduce the expression levels of hs-CRP and NT-proBNP, and reduce the occurrence of MACE.

Key words： Acute myocardial infarction Ticagrelor Percutaneous coronary intervention Oxidative stress injury Adverse cardiovascular events

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	WU Lulu
	SHI Shengjin
	LI Jiawei
	et al

Cite this article:

WU Lulu,SHI Shengjin,LI Jiawei, et al. Effects of Ticagrelor Combined with PCI on Oxidative Stress Injury Cardiac Function and Adverse Cardiovascular Events in Elderly Patients with Acute Myocardial Infarction[J]. HeBei Med, 2024, 30(4): 586-592.

URL:

http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2024.04.011 OR http://www.hbyxzzs.cn/EN/Y2024/V30/I4/586

[1] 刘金林,赵世林,肖竹青.急性心肌梗死患者血清NT-proBNP、VEGF、ox-LDL水平与LVEF的关系[J].分子诊断与治疗杂志,2022,14(4):685-687,692.
[2] 冉晨光,韩佳,赵娜.比伐卢定联合挽救性PCI治疗老年急性心肌梗死溶栓失败患者的疗效及预后评价[J].临床和实验医学杂志,2022,21(7):699-702.
[3] 方昱,曹洁,许恩文,等.替格瑞洛联合阿司匹林治疗老年急性心肌梗死的心血管事件发生[J].中国老年学杂志,2021,41(13):2692-2695.
[4] Liang J,Anderson K.Should postprocedure anticoagulation be routinely needed in acute STEMI patients undergoing primary PCI[J]JACC Cardiovasc Interv,2022,15(9):1000-1001.
[5] 于学忠,郭树彬,张新超,等.急性冠脉综合征临床实践指南(一)[J].中国急救医学,2015(12):1063-1067.
[6] 范利斌,范乾晖,范松,等.24h动态心电图参数对急性心肌梗死患者恶性室性心律失常的诊断价值[J].山东医药,2023,63(1):65-68.
[7] 崔秀平,闫伟,何金红.替格瑞洛联合丹红注射液治疗急性心肌梗死PCI术后患者临床疗效分析[J].广西医科大学学报,2021,38(8):1609-1614.
[8] 王宁宁,张凤梅,徐新禹,等.不同剂量替格瑞洛在老年急性心肌梗死病人PCI术后抗血小板治疗中的有效性与安全性[J].实用老年医学,2021,35(3):246-249.
[9] Gimbel M,Qaderdan K,Willemsen L,et al.Clopidogrel versus ticagrelor or prasugrel in patients aged 70 years or older with non-ST-elevation acute coronary syndrome (POPular AGE):the randomised,open-label,non-inferiority trial[J].Lancet,2020,395(10233):1374-1381.
[10] Kim BK,Hong SJ,Cho YH,et al.Effect of ticagrelor monotherapy vs ticagrelor with aspirin on major bleeding and cardiovascular events in patients with acute coronary syndrome:the TICO randomized clinical trial[J].JAMA,2020,323(23):2407-2416.
[11] Wang Y,Wu H,Chen Y,et al.Ticagrelor pharmacokinetics and pharmacodynamics in Chinese patients with STEMI and NSTEMI without opioid administration[J].Adv Ther,2020,37(10):4220-4232.
[12] 杨振声,游伟,蔡炜标.替格瑞洛联合依折麦布对老年急性心肌梗死患者PCI术后不良心血管事件的预防价值[J].中国临床研究,2023,36(2):258-262.