相关细胞因子对不孕症的影响分析及育龄期女性子宫内膜异位症预测模型构建

doi:10.3969/j.issn.1006-6233.2024.03.025

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Abstract Objective: To analyze the influence of related cytokines on infertility and to establish a prediction model for infertility after treatment of women of reproductive age with endometriosis.Methods: A total of 108 cases of women of reproductive age with endometriosis from March 2020 to March 2022 were included in the study. They were followed up for one year to observe their natural pregnancy. According to the pregnancy results, they were divided into natural pregnancy group and infertility group. The baseline data and serological test indicators of the two groups were compared to establish a female endometriosis model of reproductive age and analyze the effects of related cytokines on infertility. Results: One year follow-up showed that among 108 women of reproductive age with endometriosis, 66 cases (61.11%) were pregnant successfully and 42 cases (38.89%) were not. The proportion of patients with endometriosis in stage Ⅲ~Ⅳ and not receiving ovulation induction in the infertility group was higher than that in the natural pregnancy group (χ²=6.495 and 5.945, P<0.05). The levels of IL-1β, IL-18 and TNF-α in the infertility group were higher than those in the natural pregnancy group (t=7.345, 4.095, 5.739, P<0.05). The ROC curve of serum cytokine levels predicting infertility in women of reproductive age with endometriosis was drawn, and the results showed that IL-1β, IL-18, and TNF-α levels had certain predictive value for infertility in women of reproductive age with endometriosis (AUC=0.837, 0.711, 0.779, P<0.05). After logistic regression analysis, the results showed that endometriosis stage Ⅲ~Ⅳ, not receiving ovulation induction therapy, high IL-1β, IL-18, and TNF-α levels were risk factors for infertility in female endometriosis patients of reproductive age (OR = 4.730, 4.173, 16.216, 1.012, and 4.631, P<0.05), which was brought into the regression equation to obtain: logit (P) = -15.285 + 1.554X1 + 1.429X2 + 2.786X3 + 0.012X4 + 1.533X5. Conclusion: Endometriosis stage Ⅲ~Ⅳ, not receiving ovulation induction therapy, high IL-1β, IL-18, and TNF-α levels are the risk factors for infertility in women of childbearing age with endometriosis. The established Logistic regression model can predict the possibility of infertility in women of childbearing age with endometriosis, and it is helpful for medical staff to identify high-risk infertility patients.

Key words： Endometriosis Women of reproductive age Cytokines Barrenness

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	JIN Fengmei
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JIN Fengmei,MA Qingjie,et al. Analysis of the Effects of Relevant Cytokines on Infertility and Construction of a Predictive Model for Endometriosis in Women of Reproductive Age[J]. HeBei Med, 2024, 30(3): 488-492.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2024.03.025 OR http://www.hbyxzzs.cn/EN/Y2024/V30/I3/488

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