NT-pro BNP在老年心力衰竭合并衰弱诊断及预后评估的应用价值

doi:10.3969/j.issn.1006-6233.2024.02.016

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Abstract Objective: To explore the application value of N-terminal pro-B-type natriuretic peptide (NT-pro BNP) in the diagnosis of elderly heart failure with frailty and assessment of prognosis. Methods: A total of 115 cases of elderly heart failure from January 2020 to March 2022 were selected. According to the Fried frailty diagnostic scale, patients were divided into frailty group, pre-frailty group, and non-frailty group. The diagnostic value of NT-pro BNP level for frailty and its correlation with frailty severity were analyzed. The frailty group was further divided into a better prognosis group and a poor prognosis group based on major adverse events occurring within 12 months of enrollment, and the prognostic value of NT-pro BNP level was analyzed. Results: The levels of NT-pro BNP, BNP, cTnⅠ, CK, and CK-MB in the frailty group, pre-frailty group, and non-frailty group showed a decreasing trend. The indicators in the frailty group were higher than those in the pre-frailty group, and the pre-frailty group was higher than the non-frailty group (P<0.05). The AUC value of NT-pro BNP level for diagnosing frailty in elderly heart failure patients was 0.773, with a 95% CI of 0.6850.889, P<0.001, sensitivity of 87.10%, and specificity of 70.00%. Conclusion: NT-pro BNP levels are abnormally elevated in elderly heart failure patients with frailty. This marker has diagnostic value for frailty and prognostic assessment in patients, providing valuable insights into their diagnosis and prognosis.

Key words： Heart failure Elderly patients Frailty N-terminal pro-B-type natriuretic peptide Diagnostic value Prognostic assessment value

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	YE Fei
	CHEN Dandan
	YAO Yao

Cite this article:

YE Fei,CHEN Dandan,YAO Yao. Application Value of NT-pro BNP in the Diagnosis of Frailty and Prognostic Assessment in Elderly Heart Failure Patients[J]. HeBei Med, 2024, 30(2): 259-263.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2024.02.016 OR http://www.hbyxzzs.cn/EN/Y2024/V30/I2/259

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