|
|
|
| Expression and Clinical Significance of Stanniocalcin 2 (STC2) in Cervical Cancer Tissues |
| DENG Rundao, FU Xiafei |
| Zhujiang Hospital of Southern Medical University, Guangdong Guangzhou 510220, China |
|
|
|
|
Abstract Objective: To investigate the expression of calcitonin STC2 in cervical cancer tissue and evaluate its clinical significance. Methods: A retrospective study was conducted on cervical cancer patients (n=88) from Dongguan People's Hospital from January 2022to May 2022. Immunohistochemical method was used to determine the expression of STC2 in cervical tissue of patients. Real time fluorescence quantitative PCR was used to detect the gray value of STC2. compare the grayscale values of STC2 mRNA between cervical cancer tissue and normal tissue, analyze the expression of STC2 in different clinical characteristics of cervical cancer, and perform logistic regression analysis on their correlation. Results: The grayscale values of STC2 mRNA in cervical cancer tissues were higher than those in adjacent tissues, with statistical significance (P<0.05); The positive expression of STC2 in cervical cancer tissue showed statistically significant differences in different infiltration depths, differentiation levels, lymph node metastasis, and TNM staging, P<0.05; Multivariate logistic regression analysis showed that depth of infiltration, degree of differentiation, lymph node metastasis, and TNM staging were independent influencing factors for STC2 positivity; The 5-year Overall survival(OS) and Progression-Free Survival(PFS) of the STC2 positive group were lower than those of the STC2 negative group, with a statistically significant difference (P<0.05); Pearson analysis showed that the expression of STC2 was negatively correlated with OS and PFS (r=-0.747, -0.683, P<0.05). Conclusion: STC2 has a high expression in cervical cancer tissues, which has nothing to do with age, tumor diameter, pathological classification, depth of invasion, degree of differentiation and TNM stage, but is related to lymph node metastasis, which should be paid greatattention to.
|
|
|
|
|
|
[1] 李小婷,张启迪,原芸姿.宫颈癌发病年轻化的趋势分析及预防对策探讨[J].中文科技期刊数据库(全文版)医药卫生,2021,(8):160-162.
[2] 黄林飞,潘晟,夏甘霖,等.斯钙素在甲胎蛋白阳性胃癌组织中的表达及对预后的预测价值研究[J].临床外科杂志,2021,29(2):148-150.
[3] 中国抗癌协会妇科肿瘤专业委员会.子宫颈癌诊断与治疗指南(2021年版)[J].中国癌症杂志,2021,31(6):474-489.
[4] 张云珠,王宇华,王梅,等.高危型人乳头瘤病毒感染宫颈癌组织中N-myc下游调节基因1蛋白表达及其临床意义分析[J].癌症进展,2022,20(22):2363-2366.
[5] Tesfaw K,Kindie W,Mulatu K,et al.Utilisation of cervical cancer screening and factors associated with screening utilisation among women aged 30-49 years in Mertule Mariam Town,East Gojjam Zone,Ethiopia,in 2021:a cross-sectional survey[J].BMJ Open,2022,22(11):67229.
[6] 童薇,张敬,朱艳丽,等.食管鳞癌中STC2、MMP-9及PCNA表达情况[J].实用癌症杂志,2020,35(3):388-390,402.
[7] Zhang L,Wei Z,Wang Y,et al.Long noncoding RNA ROR1-AS1 enhances STC2-mediated cell growth and autophagy in cervical cancer through miR-670-3p[J].Recept Signal Transduct Res,2021,41(6):582-592.
[8] Jiang ZH,Shen X,Wei Y,et al.A pan-cancer analysis reveals the prognostic and immunotherapeutic value of stanniocalcin-2 (STC2)[J].Front Genet,2022,22(13):927046.
[9] 余计赏,谭国钳,吴帆,等.斯钙素2基因调控肝癌细胞增殖凋亡的机制[J].中华实验外科杂志,2020,37(10):1812-1814.
[10] 张月华,莫晓嫦,房惠琼.斯钙素-2、细胞-间充质上皮转化因子在宫颈癌组织中的表达及临床意义分析[J].中国医师进修杂志,2023,46(4):353-356.
[11] 付长红,陆晓媛.斯钙素-2在子宫内膜癌中的表达[J].安徽医药,2020,24(1):144-146. |
|
|
|
2024, Vol. 30 
