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Serum Levels of Carbohydrate Antigen 125 (CA125) Growth Differentiation Factor-15 (GDF-15) and Soluble Triggering Receptor Expressed on Myeloid Cells-1 (sTREM-1) in Patients with Chronic Heart Failure and their Correlation with Cardiac Function: An Analysis |
ZHANG Guoyong, MA Zheng, ZHANG Lin, et al |
Beijing Tongren Hospital Affiliated to Capital Medical University, Beijing 100730, China |
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Abstract Objective: To explore the expression of serum carbohydrate antigen 125(CA125), growth differentiation factor -15(GDF-15) and soluble myeloid cell trigger receptor -1(sTREM-1) in patients with chronic heart failure and their correlation with cardiac function. Methods: The clinical data of 96 patients with CHF admitted to our hospital from June 2022 to June 2023 were analyzed retrospectively, including 46 patients with mild and moderate heart failure (NYHA grade Ⅰ-Ⅲ) and 50 patients with severe heart failure (NYHA grade Ⅳ). In addition, 48 healthy people who underwent physical examination in our hospital during the same period were selected as the healthy control group according to the ratio of 2:1. The serum levels of CA125, GDF15 and sTREM-1 were compared with the cardiac function indexes, and the correlation between the serum levels of CA125, GDF15 and sTREM-1 and the cardiac function indexes was analyzed. The ROC curve was used to analyze the efficacy of serum levels of CA125, GDF15 and sTREM-1 in diagnosing chronic heart failure. Results: The levels of CA125, GDF15, and sTREM-1 in the study group were higher than those in the control group (P<0.05). FS and EF in the study group were lower than those in the control group, while LAD and LVEDD were higher than those in the control group (P<0.05). Person correlation analysis showed that CA125, GDF15, and sTREM-1 were negatively correlated with FS and EF (r=-0.605/-0.617, -0.516/-0.512, -0.572/-0.613, P<0.05), and positively correlated with LAD and LVEDD (r=0.827/0.818, 0.819/0.834, 0.846/0.878, P<0.05). The levels of CA125, GDF15, and sTREM-1 in the severe heart failure group were higher than those in the mild to moderate heart failure group (P<0.05). Binary Logistic Regression Analysis showed that serum CA125, GDF15, and sTREM-1 were risk factors for severe heart failure (P<0.05). The AUC, sensitivity, and specificity of serum CA125, GDF15, and sTREM-1 in evaluating the severity of chronic heart failure were 0.761, 0.695, and 0.822, respectively. The AUC for assessing the severity of chronic heart failure by prediction scoring ROC curves was 0.848 with a sensitivity of 84.0% and a specificity of 82.6%. Conclusion: Serum levels of CA125, GDF15, and sTREM-1 are upregulated in patients with CHF and are closely related to cardiac function. They can be used as effective indicators to evaluate the severity of heart failure, with better combined evaluation performance.
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[1] 胡广梅,蒋金良,段朝晖.探讨CA125、NT-proBNP在慢性心力衰竭患者中危险评估的价值[J].检验医学与临床,2022,19(2):84-87. [2] 舒红军,郭靖涛,周江,等.急性冠脉综合征患者血清GDF-15 YKL-40水平 及颈动脉硬化与冠状动脉病变程度的关系[J].河北医学,2019,25(6):919-922. [3] 赵茜,董晓茜,姜冲,等,等.老年慢性心力衰竭患者血清suPAR、PAI-1表达与预后的相关性研究[J].中国循证心血管医学杂志,2022,14(8):936-939. [4] 王建旗,刘杰,傅研,等.2001年欧洲慢性心力衰竭诊治指南概要[J].中国医药导刊,2002,4(2):79-88. [5] Vindhyal M,Lu L,Acharya P,et al.1201:impact of underlying chronic heart failure on in-hospital outcomes in patients with septic shock[J].Critical Care Medicine,2021,49(1):603. [6] Xu J,Zhang Z,Liu J,et al.Effect of traditional Asian exercise on patients with chronic heart failure:a protocol for network meta-analysis of randomised controlled trials[J].BMJ Open,2021,11(8):48891. [7] 路轶晴,段雯婷.血清IL-1,IL-6,CA125,BNP及hsCRP水平用于评估慢性心力衰竭的临床价值[J].贵阳医学院学报,2021,46(1):115-119. [8] 饶小娇,边洋,王彬宇,等.老年慢性心力衰竭患者血清中胰岛素样生长因子-1和肾损伤分子-1表达水平变化及对预后的影响[J].新乡医学院学报,2023,40(4):324-328. [9] 睢勇,孙慧,幺传为,等.慢性心力衰竭患者预后不良的血清学预测指标研究[J].实用临床医药杂志,2021,25(21):52-57. |
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