小儿动态心电图不同时段参数与感染性心内膜炎赘生物的直径与数量的相关性

doi:10.3969/j.issn.1006-6233.2023.11.024

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Abstract Objective: To investigate the diagnostic value of different time parameters of Holter electrocardiography in children with infective endocarditis. Methods: A total of 90 children with suspected infective endocarditis who were treated at our hospital from January 2017 to June 2021 were selected.Among them,62 children with infective endocarditis confirmed by echocardiography and blood culture were assigned to the observation group,while the remaining 28 children were placed in the control group.Both groups underwent pediatric Holter electrocardiogram scanning.We compared various parameters at different time periods between the two groups.Enzyme-linked immunosorbent assay was used to measure serum IL-6 and cTnI levels,and serum CRP levels were determined using the immunoratio method.The diagnostic value of the diameter and number of endocardial vegetations in infective endocarditis was analyzed. Results: Compared to the control group,children in the observation group had lower values for Holter ECG parameters such as the standard deviation of normal R-R intervals (SDNN),root mean square difference of adjacent R-R intervals (rMSSD),and the percentage of R-R intervals with a standard deviation greater than 50ms (PNN50) in different time periods (P<0.05).Additionally,children with advanced infection (12h and 24h) had lower SDNN,rMSSD,and PNN50 levels than those with early infection (P<0.05).Furthermore,children with advanced infection exhibited higher serum levels of CRP,IL-6,and cTnI compared to children with early infection (P<0.05).The diameter and quantity of endocardial vegetations in children with advanced infection were lower than in those with early infection.The combined diagnosis of SDNN,rMSSD,CRP,IL-6,cTnI,and the size and quantity of vegetations demonstrated a high diagnostic value for infective endocarditis. Conclusion: Different time period parameters in pediatric Holter electrocardiography,as well as serum markers such as CRP,IL-6,and cTnI,along with the diameter and quantity of endocardial vegetations,have high diagnostic value in the context of infective endocarditis.This information provides valuable guidance for the early prevention and treatment of infective endocarditis.

Key words： Pediatric holter electrocardiogram Parameters of different time periods Infectious endocarditis Serum CRP Serum IL-6

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2023.11.024 OR http://www.hbyxzzs.cn/EN/Y2023/V29/I11/1882

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