类风湿关节炎患者血清CTX-Ⅱ HDAC3水平与免疫功能疾病活动度的相关性

doi:10.3969/j.issn.1006-6233.2023.11.015

Abstract
Figure/Table
References
Related Citation (15)

Download: PDF (1217 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective: To observe the changes in serum type Ⅱ collagen C-terminal peptide (CTX-Ⅱ) and histone deacetylase 3 (HDAC3) levels in patients with rheumatoid arthritis (RA),and to analyze their relationship with immune function and disease activity. Methods: A total of 84 RA patients (RA group) and 84 healthy people (NC group) admitted to our hospital were gathered.The changes in serum CTX-Ⅱ,HDAC3,immune function indexes [proportion of immunoglobulin (Ig) A,IgG,IgM,CD3⁺,CD4⁺,CD8⁺ T cells] and disease activity related indexes [C-reactive protein (CRP),erythrocyte sedimentation rate (ESR)] were analyzed.Pearson method was applied to analyze the correlation of serum CTX-Ⅱ and HDAC3 with immune indexes and disease activity-related indexes,respectively. Results: The levels of CTX-Ⅱ(9.26±1.84 vs 4.59±0.62) and HDAC3(83.72±13.51 vs 20.15±4.90) in the RA group were higher than those in the NC group (t=22.044,40.542,P<0.05).The levels of CTX-Ⅱ(7.37±1.71 vs 10.75±1.94) and HDAC3(72.97±12.10 vs 92.18±14.62) in the remission group were lower than those in the active group (t=8.347,7.940,P<0.05).The proportion of CD3⁺(64.42±6.91 vs 70.42±7.34) and CD4⁺(34.80±5.96 vs 39.74±5.80) T cells in the RA group was lower than that in the NC group,while the levels of CD8⁺(31.68±6.15 vs 29.62±7.15) T cells,IgM(2.06±0.39 vs 1.47±0.30),IgA(2.96±0.50 vs 1.51±0.36),IgG(15.49±3.05 vs 11.83±2.19),ESR(28.32±7.60 vs 13.75±2.18),CRP(10.94±2.02 vs 6.08±0.73) were obviously higher than those in the NC group (P<0.05).The CD3⁺(62.94±6.60 vs 66.30±7.30) and CD4⁺(33.57±5.74 vs 36.36±6.24) T cells in the active group were lower than those in the remission group,and the levels of IgM(2.19±0.41 vs 1.89±0.36),IgA(3.08±0.54 vs 2.81±0.45),IgG(16.16±3.27 vs 14.64±2.77),ESR(30.06±8.15 vs 26.11±6.90),CRP(12.37±2.24 vs 9.12±1.74) were higher than those in the remission group (P<0.05).Correlation analysis showed that serum CTX-Ⅱ was positively correlated with ESR,CRP and disease activity score in 28 joints (DAS28) (r=0.572,0.495,0.809,all P=0.000); serum HDAC3 was negatively correlated with the proportions of CD3⁺ and CD4⁺ T cells,respectively (r=-0.529,-0.464,P=0.000),and was positively correlated with IgM,IgA,IgG,ESR,CRP and DAS28 (r=0.460,0.491,0.445,0.540,0.519,0.864,all P<0.05). Conclusion: Serum levels of CTX-Ⅱ and HDAC3 are elevated in RA patients compared to healthy individuals.CTX-Ⅱ is associated with disease activity in RA,while HDAC3 is related to immune dysfunction and disease activity.

Key words： Rheumatoid arthritis Type Ⅱ collagen C-terminal peptide Histone deacetylase 3 Immunoglobulin T lymphocyte subsets Disease activity Correlation

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors

Cite this article:

URL:

http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2023.11.015 OR http://www.hbyxzzs.cn/EN/Y2023/V29/I11/1837

[1] Maeda K,Yoshida K,Nishizawa T,et al.Inflammation and bone metabolism in rheumatoid arthritis:molecular mechanisms of joint destruction and pharmacological treatments[J].Int Mol Sci,2022,23(5):2871-2894.
[2] 吕建敏,刘广宇,赵海河,等.温针灸配合独活寄生汤治疗类风湿性关节炎临床研究[J].陕西中医,2022,43(11):1613-1616,1620.
[3] Zhao J,Guo S,Schrodi SJ,et al.Molecular and cellular heterogeneity in rheumatoid arthritis:mechanisms and clinical implications[J].Front Immunol,2021,12(1):1-21.
[4] 安新,冯超,高利常.类风湿关节炎患者血清白细胞介素-32、白细胞介素-17和白细胞介素-10表达水平及临床意义[J].陕西医学杂志,2021,50(12):1585-1588.
[5] Idriss NK,Gamal RM,Gaber MA,et al.Joint remodeling outcome of serum levels of Dickkopf-1 (DKK1),cartilage oligomeric matrix protein (COMP),and C-telopeptide of type Ⅱ collagen (CTXⅡ) in rheumatoid arthritis[J].Cent Eur Immunol,2020,45(1):73-79.
[6] 张赫.HDAC3在运动治疗骨性关节炎中的作用和机制研究[D].中国医科大学,2020.
[7] 中华医学会风湿病学分会.2018中国类风湿关节炎诊疗指南[J].中华内科杂志,2018,57(4):242-251.
[8] 邱贵兴.类风湿关节炎的诊断与治疗骨科专家共识[J].中华骨科杂志,2012,32(12):1184-186.
[9] 巴燕·艾克海提,古洁乃特汗·拜克里木.加味四妙勇安汤联合艾灸治疗类风湿性关节炎疗效研究[J].陕西中医,2022,43(3):314-317.
[10] 王晓亮,郑伟,赵娜,等.类风湿关节炎患者血清IL-35,MMP-3,Gal-1水平及其与免疫功能指标的相关性研究[J].现代检验医学杂志,2022,37(2):71-75.
[11] 邹晓军.Tim-3血清水平对类风湿性关节炎疾病进展与免疫功能的影响[J].中国现代医药杂志,2021,23(10):22-25.
[12] 赵伊婷,何云,马洁.CTX-Ⅱ检测对早期KOA患者的诊断价值研究[J].河北医药,2021,43(17):2580-2584.
[13] Wilfahrt D,Philips RL,Lama J,et al.Histone deacetylase 3 represses cholesterol efflux during CD4⁺ T-cell activation[J].Elife,2021,10(1):1-25.