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| Analysis of the Efficacy of Cyclosporin A-based Compound Medication Regimen in the Treatment of Non-Severe Aplastic Anemia |
| WEI Shujuan, WANG Jing, LU Wenyan, et al |
| Xijing Hospital, The First Affiliated Hospital of Air Force Military Medical University of People's Liberation Army, Shaanxi Xi'an 710032, China |
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Abstract Objective: To study the efficacy of compound Zaofan pills combined with cyclosporine A and testosterone undecanoate in the treatment of non-severe aplastic anemia (NSAA). Methods: A retrospective analysis was performed on 80 patients with NSAA admitted to the hospital from January 2020 to January 2023. According to the treatment methods, they were divided into study group (40 cases) and control group (40 cases). The study group was treated with compound Zaofan pills combined with cyclosporine A and testosterone undecanoate, and the control group was treated with cyclosporine A and stanazolol. The lymphocyte subsets (CD4+, CD8+), white blood cell count, platelet count, hemoglobin level before and after treatment, liver function indexes [serum alkaline phosphatase (ALP), glutamyltransferase (GGT), aspartate aminotransferase (AST), alanine aminotransferase (ALT)], total effective rate, side effects (toxic side effects, liver function) were compared between the two groups. Results: There were no significant differences in CD4+, CD8+, white blood cell count, platelet count and hemoglobin level between the two groups before treatment (P>0.05). Compared with before treatment, CD4+, white blood cell count, platelet count and hemoglobin level were higher in the two groups after treatment, and CD8+ was lower, the difference was statistically significant (P<0.05). Compared with the control group, the CD4+, white blood cell count, platelet count, hemoglobin level and total effective rate of the study group were higher, and the CD8+, ALP, GGT, AST, ALT levels and the incidence of toxic side effects and abnormal liver function were lower, the differences were statistically significant (P<0.05). Conclusion: Compound Zaofan pill combined with cyclosporine A and testosterone undecanoate is effective in the treatment of patients with NSAA, which can enhance the cellular immune function, improve white blood cell count, platelet count and hemoglobin level, and reduce the degree of liver damage, with few side effects and high safety.
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2023, Vol. 29 
