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| Effect of Bovine Pulmonary Surfactant Combined with Caffeine on Blood Gas Markers, Inflammatory Indexes and Pulmonary Circulation Function in Children with Neonatal Pulmonary Hyaline Membrane Disease |
| HUANG Xiaowei, SU Hongmiao, et al |
| Qionghai People's Hospital, Hainan Qionghai 571400, China |
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Abstract Objective: To explore the effect of pulmonary surfactant combined with caffeine on blood gas markers, inflammatory indexes, and pulmonary circulation function in children with neonatal pulmonary membrane disease. Methods: A total of 145 newborns with pulmonary dialysis who received treatment in our hospital from January 2020 to December 2022 were included as the study subjects. The children were randomly divided into two groups using simple random grouping of children using computer randomization method. The control group (n=72) received caffeine citrate treatment, while the observation group (n=73) received bovine lung surfactant combined with caffeine treatment. The clinical data of the two groups of children were collected to compare the blood gas markers, inflammatory factor levels and pulmonary circulation function before and after treatment, and to compare the differences in treatment effects between the groups. Results: The response rate of the observation group was 86.30%, higher than 73.61% in the control group (P<0.05). After treatment, the blood gas indexes of the children improved, the pO2, BE, and pH values increased significantly, but the pCO2 level of the children was significantly reduced, and the blood gas index of the observation group improved more than that of the control group (P<0.05). IL-6 and LDH in the two groups were at the same level (P>0.05); after treatment, IL-6 levels in the children increased first and decreased, LDH levels decreased over time, and the IL-6 and LDH levels in the observation group were lower than the corresponding time node in the control group (P<0.05). There was no significant difference in the pulmonary circulation function (P>0.05). After treatment, the EVLW, PVR and MPAP all decreased, and the RVSWI level increased, and the increase and decrease of the observation group were higher than those of the control group, with a significant difference (P<0.05). Conclusion: In the treatment of neonatal pulmonary transparent membrane disease, the treatment of cow pulmonary surfactant combined with caffeine can effectively improve the blood gas and inflammation index of children, improve the pulmonary circulation function of children, and effectively improve the treatment effect.
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2023, Vol. 29 
