联合检测NT-proBNP 肌酐血红蛋白对慢性心力衰竭患者预后的预测价值

doi:10.3969/j.issn.1006-6233.2023.10.011

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Abstract Objective: To analyze the prognostic value of NT-proBNP, creatinine and hemoglobin in patients with chronic heart failure. Methods: The clinical data of 220 patients with CHF from March 2020 to March 2021 were retrospectively analyzed. The patients were followed up for 1 year and divided into good prognosis group (n=141) and poor prognosis group (n=79) according to whether the patients had concurrent adverse events. The levels of NT-proBNP, creatinine and hemoglobin in the two groups were compared, and the prognostic risk factors of CHF patients were analyzed by multivariate Logistic regression. Pearson method was used to analyze the correlation of serum NT-proBNP, creatinine and hemoglobin with left ventricular ejection fraction (LVEF) and left ventricular end-diastolic diameter (LVEDD) in the case group. The area under receiver operating characteristic (ROC) curve (AUC) evaluated the value of NT-proBNP, creatinine and hemoglobin in predicting the prognosis of CHF. Results: The levels of NT-proBNP and creatinine in poor prognosis group were higher than those in good prognosis group (P<0.05), and the levels of hemoglobin in poor prognosis group were lower than those in good prognosis group (P<0.05); Multifactor stepwise binary Logistic regression analysis showed that the levels of NT-proBNP, creatinine and hemoglobin were independent risk factors affecting the prognosis of CHF (P<0.05); Pearson correlation analysis showed that NT-proBNP, creatinine and hemoglobin were significantly correlated with LEVF and LVEDD in CHF patients (P<0.05); with the increase of NYHA grade, the levels of NT-proBNP and creatinine were increased (P<0.05), while the hemoglobin level was decreased (P<0.05); ROC curve showed that the AUC of NT-proBNP, creatinine, hemoglobin, and their combination in predicting the prognosis of CHF was 0.765,0.656,0.720,0.866, and the sensitivity was 60.8%,46.8%,53.2% and 86.1%, respectively,the specificity was 83.0%,91.5%,83.7% and 73.8%. Conclusion: NT-proBNP, creatinine and hemoglobin are correlated with the severity of heart failure in CHF patients, and the combined detection has better efficacy in predicting the prognosis of CHF patients, and the combined detection has higher clinical value than the single factor detection.

Key words： Amino-termianlpro-brain natriuretic peptide Creatinine Hemoglobin Chronic heart failure Prognosis

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2023.10.011 OR http://www.hbyxzzs.cn/EN/Y2023/V29/I10/1644

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