血清SCC M-CSF Chemerin水平对宫颈上皮内瘤变患者诊断评估价值

doi:10.3969/j.issn.1006-6233.2023.09.08

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Abstract Objective: To investigate the changes of serum squamous cell carcinoma antigen (SCC), macrophage colony stimulating factor (M-CSF), and chemokine (Chemrin) in patients with cervical epithelial neoplasia and their diagnostic value. Methods: A total of 101 patients with cervical epithelial neoplasia (CIN) confirmed by pathological examination in our hospital from April 2019 to April 2022 were selected as the CIN group, and 50 patients with early cervical cancer confirmed by pathological examination in the same period were selected as the cervical cancer group. The measured values of serum SCC, M-CSF, and Chemerin before treatment were compared between the two groups, and the hierarchical comparative analysis was carried out according to the CIN stage and the results of high-risk human papillomavirus (HR-HPV) viral load test. The levels of serum SCC, M-CSF and Chemerin in CIN patients before and 3 months after operation were compared. The application value of SCC, M-CSF and Chemerin in the differential diagnosis of CIN and early cervical cancer was analyzed by the subject working characteristic curve (ROC). Results: The measured values of serum SCC, M-CSF and Chemerin in patients with cervical cancer were significantly higher than those in patients with CIN (P<0.05). The areas under ROC curve of SCC, M-CSF and Chemerin were 0.906, 0.846 and 0.791, respectively. Among the 101 patients with CIN, there were 21 patients with stage I, 46 patients with stage II, and 34 patients with stage III. With the increase of CIN stage, the levels of SCC, M-CSF, and Chemerin in the patients increased gradually, and the difference between the groups was statistically significant (P<0.05). The measured values of SCC and M-CSF in patients with HR-HPV DNA positive CIN were higher than those in patients with negative CIN, and the difference between the groups was statistically significant (P<0.05). Three months after the operation, the measured values of SCC, M-CSF and Chemerin in CIN patients showed a significant downward trend, and the difference was statistically significant (P<0.05). Conclusion: Compared with cervical cancer patients, the determination values of SCC, M-CSF and Chemerin in CIN patients were lower, but with the increase of CIN grading and the higher levels of SCC, M-CSF and Chemerin in patients with positive expression of HR-HPV DNA, Detection of SCC, M-CSF and Chemerin levels can differentiate CIN from cervical cancer.

Key words： Cervical epithelial neoplasia Squamous cell carcinoma antigen Macrophage colony stimulating factor Chemokinin

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	SUN Li
	SONG Yurong
	HU Pin
	et al

Cite this article:

SUN Li,SONG Yurong,HU Pin, et al. Diagnostic Value of Serum SCC M-CSF and Chemerin Levels in Patients with Cervical Intraepithelial Neoplasia[J]. HeBei Med, 2023, 29(9): 1447-1451.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2023.09.08 OR http://www.hbyxzzs.cn/EN/Y2023/V29/I9/1447

[1] 林俊.高级别宫颈上皮内瘤变宫颈锥切术后高危型人乳头瘤病毒转归影响因素[J].中国计划生育学杂志,2022,30(5):1098-1101.
[2] Rrbine Donken,Dirk Van Niekerk,Jeremy Hamm,et al.Declining rates of cervical intraepithelial neoplasia in british columbia,canada:an ecological analysis on the effects of the school-based human papillomavirus vaccination program[J].International Journal of Cancer,2021,149(1):191-199.
[3] 游伟强,吴小延,王莉平,等.外周血循环肿瘤细胞联合鳞状细胞癌抗原检测在子宫颈微小浸润性鳞状细胞癌诊断中的价值[J].热带医学杂志,2022,22(7):915-919,924.
[4] 王晓林,李凤梅,王雅莉,等.血清M-CSF、TSGF、SCC-Ag在宫颈癌诊断中的应用分析[J].实用癌症杂志,2021,36(6):924-926.
[5] 豆秋彦,冯文,李春霖.脂肪因子chemerin在女性常见恶性肿瘤中的作用研究进展[J].新乡医学院学报,2020,37(12):1195-1200.
[6] 中华人民共和国国家卫生和计划生育委员会.宫颈癌及癌前病变规范化诊疗指南(试行)[J].中国医学前沿杂志(电子版),2013,5(8):40-49.
[7] 李道娟,师金,靳晶,等.宫颈癌的流行病学趋势[J].中华肿瘤杂志,2021,43(9):912-916.
[8] 王鹏,孙喜斌,乔友林,等.高危型HPV分型检测对早期宫颈癌诊断的意义[J].中华医学杂志,2020,100(18):1396-1400.
[9] 陈号,夏昌发,由婷婷,等.中国女性宫颈癌负担快速上升的原因及其应对措施[J].中华流行病学杂志,2022,43(5):761-765.
[10] Fernndez-montolm-E,Tous S,Medina G,et al.Long-term predictors of residual or recurrent cervical intraepithelial neoplasia 2-3 after treatment with a large loop excision of the transformation zone:a retrospective study[J].BJOG:an international journal of obstetrics and gynaecology,2020,127(3):377-387.
[11] 李静,刘静,张燕.宫颈癌患者血清鳞状细胞癌抗原、尿激酶型纤溶酶原激活物受体、CD105、转化生长因子-β水平及临床意义[J].癌症进展,2021,19(13):1367-1370.
[12] 陈远平,杜仲,袁竟,等.M-CSF、CA153、HPV联合检测在宫颈癌早期筛查中的临床意义[J].国际检验医学杂志,2020,41(6):667-670.
[13] 张淑艳,武鑫瑞,王君喆,等.高危型人乳头瘤病毒检测联合液基薄层细胞学检查在宫颈病变筛查中的诊断价值分析[J].标记免疫分析与临床,2022,29(6):958-961,1051.