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| The Relationship between C-reactive Protein and Non-Invasive Ventilation in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease Complicated with Type II Respiratory Failure |
| YANG Yi, LI Qun, HE Mengjun, et al |
| Chengdu Third People's Hospital, Sichuan Chengdu 610031, China |
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Abstract Objective: To investigate the relationship between the levels of C-reactive protein (CRP), suppression of tumorigenicity 2 (ST2), procalcitonin (PCT), lactic acid, and non-invasive ventilation in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) complicated with respiratory failure. Methods: A total of 146 patients with AECOPD and type II respiratory failure treated in our hospital from January 2021 to June 2022 were selected as the observation group, and 100 patients with simple AECOPD were selected as the control group. The levels of CRP, ST2, PCT and lactic acid in the observation group and the control group were compared. The observation group was given non-invasive ventilation treatment, and the clinical data, CRP, ST2, PCT and lactic acid levels of patients with treatment failure and success were compared. Results: The levels of CRP, ST2, PCT and lactic acid in the observation group were significantly higher than those in the control group (P<0.05). The course of COPD, APACHE Ⅱ score, fasting blood glucose, CRP, ST2, PCT and lactic acid levels of patients with treatment failure in the observation group were significantly higher than those of patients with treatment success (P<0.05). Logistic regression analysis showed that APACHE Ⅱ score, CRP, ST2, PCT and lactic acid were the influencing factors for the failure of noninvasive ventilation treatment (P<0.05). The area under the ROC curve of APACHE Ⅱ score, CRP, ST2, PCT, lactic acid and the combination of them to predict treatment failure were 0.662, 0.698, 0.717, 0.658, 0.759 and 0.806 respectively (P<0.05). Conclusion: The levels of CRP, ST2, PCT and lactic acid in AECOPD patients with type II respiratory failure increased significantly. The evaluation based on the patient's disease progress and APACHE Ⅱ score, CRP, ST2, PCT and LCR can provide a more comprehensive reference and basis for predicting the effect of ventilation treatment.
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2023, Vol. 29 
