单孔胸腔镜精准肺段切除术与肺叶切除术治疗早期非小细胞肺癌的临床疗效对比

doi:10.3969/j.issn.1006-6233.2023.09.017

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Abstract Objective: To compare and analyze the clinical curative effect of two single-port thoracoscopy on early non-small cell lung cancer (NSCLC). Methods: A retrospective analysis was performed on the clinical data of 108 patients with early NSCLC admitted to the hospital between January 2020 and October 2022. According to different surgical methods, they were divided into single-port thoracoscopic precise segmentectomy group (group A, 58 cases) and lobectomy group (group B, 50 cases). All were followed up for 5 months after surgery. The differences in perioperative indexes (total number of lymph nodes dissection, intraoperative blood loss, operation time, indwelling time of thoracic catheter, thoracic drainage volume, hospitalization time), tumor markers [cytokeratin-19-fragment (CYFRA21-1), carcinoembryonic antigen (CEA), carbohydrate antigen 50 (CA50)], lung function indexes [peak expiratory flow (PEF), forced vital capacity (FVC), forced expiratory volume in one second (FEV1)], differences in the Quality of Survival in Lung Cancer Scale (EORTC QLQ-LC43) scores, and postoperative complication rates were compared. Results: The differences in the total number of lymph node dissection, intraoperative blood loss, and complication rates between the two groups were not statistically significant (P>0.05), and the operative time in Group A was higher than that in Group B. The time of chest tube retention, chest drainage, and hospitalization were lower than that in Group B (P<0.05); the levels of CYFRA21-1, CEA, and CA50 in both groups were lower than those in the preoperative period at 3 d postoperatively (P<0.05), whereas the difference between the two groups before and after surgery was not statistically significant in the same group (P>0.05); at 5 months postoperatively, the levels of PEF, FVC, and FEV1 were lower than those in the preoperative period in both groups, whereas the decrease in group A was smaller than that in group B, with a smaller difference between the pre- and post-surgical periods (P<0.05); after 5 postoperative months, all EORTC QLQ-LC43 scores in group A were higher than those in group B (P<0.05).Conclusion: The single-port thoracoscopic lobectomy and segmentectomy have comparable curative effect and safety. However, the latter is more beneficial to shorten the rehabilitation process, improve lung function and quality of life.

Key words： Early non-small cell lung cancer Single-port thoracoscope Segmentectomy Lobectomy Clinical curative effect

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2023.09.017 OR http://www.hbyxzzs.cn/EN/Y2023/V29/I9/1502

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