miR-2116-3p和miR-342-3p对肝细胞癌诊断及预后价值的研究

doi:10.3969/j.issn.1006-6233.2023.09.011

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Abstract Objective: To investigate the clinical value of miR-342-3p and miR-2116-3p in hepatocellular carcinoma (HCC). Methods: A total of 57 samples of tumor tissues and para-tumor liver tissues from HCC patients who underwent curative resection were included in this study. The expression levels of miR-2116-3p and miR-342-3p were measured and analyzed by qRT-PCR. Results: The expression levels of miR-2116-3p and miR-342-3p in HCC tissues were significantly lower than those in adjacent tissues (P=0.034, P<0.001). ROC curve analysis showed that the two had diagnostic efficacy (P<0.05). The expression of miR-2116-3p can be used as an independent risk factor for predicting the poor prognosis of HCC patients.Conclusion: In the 57 samples of this study, miR-2116-3p as well as miR-342-3p were significantly reduced in hepatitis-associated HCC tissues, which had diagnostic value for HCC as a potential new marker; miR-2116-3p was an independent predictor of poor prognosis in HCC.

Key words： miR-2116-3p miR-342-3p Hepatocellular carcinoma Diagnostic markers Prognosis

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2023.09.011 OR http://www.hbyxzzs.cn/EN/Y2023/V29/I9/1465

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