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Effects of Oxycodone and Remifentanil Combined with Propofol on Hemodynamics, Neurological Function and Prognosis of Patients Operated for Craniocerebral Injury |
QIAO Yan, LIAO Xingzhi, CHEN Tian, et al |
904 Hospital of Joint Logistics Support Force, Jiangsu Wuxi 214044, China |
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Abstract Objective: To explore the effects of oxycodone and remifentanil combined with propofol on hemodynamics, neurological function and prognosis of patients with craniocerebral injury. Methods: A total of 150 patients with craniocerebral injury admitted from September 2019 to September 2021 were selected as the study subjects and randomly divided into study group and control group, with 75 patients in each group. The study group was given oxycodone combined with propofol, and the control group was given remifentanil combined with propofol. The levels of hemodynamics [Oxygen saturation (SpO2), mean arterial pressure (MAP), heart rate (HR)] before operation (T0), 30 minutes after anesthesia (T1), immediately after operation (T2), and 24 hours after operation (T3) were compared between the two groups, and the levels of nerve function [Tau protein (Tau), neuron-specific enolase (NSE), glial fibrillary acidic protein (GFAP)] at T0 and T3 were compared. The prognosis of the two groups was compared after 3 months follow-up. Results: The differences of SpO2, MAP and HR between the two groups and at different time points and the interaction between time and groups were statistically significant (P<0.05). At T0, there were no differences in serum Tau, NSE and GFAP levels between two groups (P>0.05). At T3, the levels of serum Tau, NSE and GFAP in both groups were lower than those at T0, and the reduction degree in the study group was greater than that in the control group (P<0.05). There were no deaths in the two groups, and the prognosis of the study group was better than that of the control group (P<0.05). Conclusion: Compared with remifentanil combined with propofol, oxycodone combined with propofol can obtain a more stable hemodynamic level in patients with craniocerebral injury, and can significantly improve the neurological function and prognosis of patients, which is more worthy of clinical application.
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[1] Yang C,Lang LJ,He ZH,et al.Epidemiological characteristics of older patients with traumatic brain injury in China[J].Neurotrauma,2022,39(11-12):850-859. [2] 曹金凤,靳乐,蒋留琴,等.瑞芬太尼复合丙泊酚麻醉对颅脑手术患者认知功能及炎症反应的影响分析[J].中南医学科学杂志,2019,47(6):613-616. [3] Hernandez MC,Bouzas MII,Garde AMDA,et al.Early prognostic factors for morbidity and mortality in severe traumatic brain injury.Experience in a child polytrauma unit[J].Med Intensiva (Engl Ed),2022,46(6):297-304. [4] 王安平,岳新霞,海力茜·陶尔大洪,等.丙泊酚对重型颅脑损伤手术患者血流动力学、术后镇痛镇静效果及血清hs-CRP、PCT、IL-22表达的影响[J].解放军医药杂志,2019,31(2):107-112. [5] 鄢润斌,袁海军,张宇帆,等.盐酸羟考酮联合丙泊酚用于颅脑创伤急诊手术的麻醉效果[J].中国临床保健杂志,2021,24(5):679-682. [6] 高三杰,张先杰,夏乐强,等.异丙酚联合瑞芬太尼对急诊颅脑损伤手术患者血流动力学及脑细胞功能的影响[J].河北医学,2020,26(8):1385-1389. [7] 陈正荣,江仁,曹维梦,等.瑞芬太尼联合丙泊酚对创伤性颅脑损伤患者围术期疼痛程度,神经功能及预后的影响[J].中国医刊,2021,56(2):226-228. [8] 卫彦峰.丙泊酚麻醉对颅脑外伤患者神经功能及氧化应激指标水平的影响[J].中国药物与临床,2021,21(11):1908-1909. [9] 严明科,姚敏学,贡伟一.围术期应用依达拉奉对重型颅脑外伤患者临床疗效及血清NSE、MBP、GFAP水平的影响[J].贵州医药,2017,41(8):826-828. |
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