D-二聚体Irisin及Caprini血栓风险评估量表评估慢阻肺合并肺栓塞预后的价值

doi:10.3969/j.issn.1006-6233.2023.08.019

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Abstract Objective: To explore the prognostic value of D-dimer (D-D), Irisin and Caprini thrombus analysis in chronic obstructive pulmonary disease patients with pulmonary embolism. Methods: A total of 151 patients with chronic obstructive pulmonary disease complicated with pulmonary embolism treated in our hospital from January 2019 to August 2022 were selected as the observation group, while 151 chronic obstructive pulmonary disease patients without complicated with pulmonary embolism were selected as the control group. The D-dimer, Irisin and Caprini thrombus Risk Assessment Scale were compared between the two groups. At the same time, the differences of D-dimer, Irisin and Caprini thrombus Risk Assessment Scale in patients with different clinical characteristics and prognosis in the observation group were analyzed. Results: The D-dimer and Caprini thrombus risk assessment scale in the observation group were (1.50±0.34) mg/L and (5.40±0.98) points respectively, which were significantly higher than those in the control group (P<0.05), while Irisin was (22.54±4.03) ng/ml, which was significantly lower than that in the control group (P<0.05). The D-dimer and Caprini thrombus risk assessment scale of extremely high-risk patients in the observation group were (1.58±0.36) mg/L and (7.89±0.91) points respectively, which were significantly higher than other patients (P<0.05), while Irisin was (19.98 ± 4.03) ng/ml, which was significantly lower than other patients (P<0.05). There was a positive correlation between D-dimer and Caprini thrombus risk assessment scale score in the observation group (r=0.465, P<0.05). Irisin in the observation group was negatively correlated with the score of the thrombus risk assessment scale (r=-0.511, P<0.05). The D-dimer and Caprini thrombus risk assessment scale of the dead patients in the observation group were (1.72±0.30) mg/L and (6.72±0.91) points respectively, which were significantly higher than those of the surviving patients (P<0.05), while Irisin was (18.89±4.12) ng/ml, which was significantly lower than those of the surviving patients (P<0.05). The area under the ROC curve of D-dimer, Irisin, Caprini thrombus risk assessment scale prediction of death in patients with chronic obstructive pulmonary disease and pulmonary embolism were 0.811, 0.715, 0.890, respectively, P<0.05. Conclusion: The D-dimer, and the Caprini Thrombus Risk Assessment Scale score of COPD patients with pulmonary embolism increase, but the level of Irisin decrease, the Caprini Thrombosis Risk Assessment Scale has a high value in evaluating the prognosis of COPD with pulmonary embolism.

Key words： D-dimer Irisin Caprini thrombosis assessment scale Chronic obstructive pulmonary disease Pulmonary embolism Prognosis

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2023.08.019 OR http://www.hbyxzzs.cn/EN/Y2023/V29/I8/1329

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