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| Application of Serum Lipase and SAA Expression in the Early Assessment of Severe Acute Pancreatitis |
| HUANG Lili, HAN Neng, LI Shujin |
| Hefei Second People's Hospital, Anhui Hefei 230011, China |
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Abstract Objective: To observe the serum lipase (LPS) and serum amyloid (SAA) expression in patients with acute pancreatitis of different severity,and analyze the application of the above serum indicators in the early assessment of patients with severe acute pancreatitis,with the aim of guiding the early treatment of patients with clinical severe acute pancreatitis and promoting benign patient outcomes. Methods: Retrospectively,baseline data of 50 patients with mild acute pancreatitis admitted to our hospital between January 2018 and January 2022 were collected and included in the mild disease group (APACHE II score <8),and baseline data of 55 patients with severe acute pancreatitis during the same period were collected and included in the severe disease group (APACHE II score ≥8),and the baseline data of the two groups were compared with serum SAA and LPS expression,and the application of the above serum indicators in the early assessment of patients with severe acute pancreatitis was analyzed. Results: There was no statistically significant difference between the age,combined hypertension,combined diabetes mellitus,combined hyperlipidemia,and gender data of the two groups (P>0.05); compared with the mild disease group,the patients in the severe disease group showed high expression of serum SAA and LPS and higher APACHE II score,and the differences were statistically significant (P<0.05); multiple logistic regression model was established,and the results showed that the expression of serum SAA and LPS before treatment was related to the severity of acute pancreatitis patients,and overexpression of serum SAA and LPS might be a risk factor for aggravation of acute pancreatitis patients (OR>1,P<0.05); the ROC curve was plotted,and the results showed that the AUC of serum SAA and LPS expression before treatment to predict heavy disease in acute pancreatitis patients were all >0.80,and the predictive value were good.The results of bivariate Spearman linear correlation analysis showed that there was a positive correlation between the pre-treatment serum SAA and LPS expression and APACHE II score in patients with acute pancreatitis. Conclusion: Serum SAA and LPS can be used for the early assessment of patients with heavy acute pancreatitis,and patients with acute pancreatitis with high serum SAA and LPS expression should be considered as heavy,and the corresponding clinical treatment should be carried out immediately to promote a favorable prognosis of patients in the future.
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2023, Vol. 29 
