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| Effect of Letrozole Combined with Clomiphene Citrate on Glycolipid Metabolism and Prognosis in Newly Treated Patients with Polycystic Ovary Syndrome |
| SUN Yunxia, RAO Yangyang, LIU Wei |
| Xuancheng People's Hospital, Anhui Xuancheng 242000, China |
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Abstract Objective: To explore the effect of letrozole (LE) combined with clomiphene citrate (CC) on glycolipid metabolism and prognosis in newly treated patients with polycystic ovary syndrome (PCOS). Methods: A random number table was used to divide 126 newly diagnosed PCOS patients admitted to the People's Hospital of Xuancheng City, Anhui Province from January 2021 to June 2022 into a control group (treated with CC alone, n=63) and an observation group (treated with LE combined with CC, n=63). Glucose and lipid metabolism-related indicators, sex hormone levels, ovulation status and adverse effects was made between the control group and the observation group before and after treatment. Results: The FPG, FINS, HOMA-IR, TG, TC, FSH, LH, E2 and T of the patients in the observation group were all significantly lower than those of the control group after treatment, and the levels of changes in these indicators before and after treatment were all significantly higher than those of the control group, and the differences were all statistically significant (P<0.05). The number of mature follicles and the diameter of mature follicles in the observation group were significantly higher than those in the control group, and the difference was statistically significant (P<0.05). There was no statistically significant difference in the incidence of adverse reactions between the observation group and the control group (P>0.05). Conclusion: LE combined with CC significantly improves glucolipid metabolism and promotes ovarian ovulation in patients with primary PCOS.
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2023, Vol. 29 
