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| The Value of Changes in Serum CRP, AMY and MPV in Diagnosis and Disease Assessment of Patients with Biliary Pancreatitis |
| HUA Lei, WEI Wei, DU Yong, et al |
| Huangshan People's Hospital, Anhui Huangshan 245000, China |
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Abstract Objective: To investigate the changes and clinical significance of serum C-reactive protein (CRP), amylase (AMY), and mean platelet volume (MPV) in patients with biliary pancreatitis. Methods: Ninety eight patients with acute biliary pancreatitis (biliary source group) and 100 patients with acute non biliary pancreatitis (control group) diagnosed at the same time in Huangshan People's Hospital from June 2019 to June 2022 were selected. The levels of CRP, AMY, MPV, liver function indicators, blood routine biochemical indicators, acute physiological function and chronic health (APACHE II) scores, and CT severity index scores (CTSI) of the two groups were compared. Simple linear correlation was used to analyze the correlation between CRP, AMY, MPV levels, APACHE Ⅱ score and CTSI. Results: There was no statistically significant difference between the two groups in serum CRP and AMY measured values (P>0.05); the measured value of MPV in peripheral blood of the biliary group was higher than that of the control group, and the difference between the above indexes was statistically significant (P<0.05); the serum ALT, AST, TBIL and DBIL of patients in the biliary group were higher than those in the control group, and the difference between the above indexes was statistically significant (P<0.05); there was no statistically significant difference in urea nitrogen, WBC, blood sugar, blood calcium, lactate dehydrogenase, hemoglobin, hematocrit, platelet count, APACHE Ⅱ score and CTSI score between the biliary group and the control group (P>0.05); the correlation analysis of CRP, AMY, MPV, APACHE Ⅱ score and CTSI score of patients in biliary group showed that there was significant positive correlation (P<0.05); the level of MPV in peripheral blood has high value in differential diagnosis of patients with acute biliary pancreatitis or acute non biliary pancreatitis, with sensitivity of 70.63%, specificity of 64.75%, AUC value of 0.746 (95% CI: 0.679-0.813), and cutoff value of ≥ 9.20 fL. Conclusion: The levels of CRP and AMY in patients with acute biliary pancreatitis or acute non-biliary pancreatitis are not significantly different, MPV is higher than that in patients with acute non-biliary pancreatitis, CRP, AMY, MPV and acute biliary pancreatitis patients Depending on the severity, MPV has a certain value in the differential diagnosis of acute biliary pancreatitis or acute non-biliary pancreatitis.
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2023, Vol. 29 
