MAGE-As 蛋白及mRNA在肺癌患者的表达水平变化及其临床意义

doi:10.3969/j.issn.1006-6233.2023.06.011

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Abstract Objective: To investigate the expression and clinical significance of melanoma associated antigen (MAGE)-As protein and mRNA in non-small cell lung cancer. Methods: A total of 88 patients with non-small cell lung cancer treated in our hospital from January 2015 to January 2020 were selected, and the adjacent tissues were selected as the control, the expression of MAGE-As protein in lung cancer and adjacent tissues was detected by Western blot, and the expression of MAGE-As mRNA in lung cancer and adjacent tissues was detected by RT-PCR. Results: The relative expression levels of MAGE-As protein and mRNA in NSCLC tissues were (0.343 ± 0.101) and (0.728 ± 0.112), which were significantly higher than those in adjacent tissues (P<0.05); the relative expression of MAGE-As protein in stage Ⅲ ~Ⅳ lung cancer was (0.385 ± 0.102), which was significantly higher than that in stage Ⅰ~ Ⅱ lung cancer (P<0.05); there were no significant difference in the relative expression of MAGE-As protein in different gender, age, tumor diameter, pathological type and differentiation degree (P>0.05); the relative expression of MAGE-As mRNA in clinical stage Ⅲ~ Ⅳ and moderately and moderately differentiated lung cancer tissues were (0.762 ± 0.112) and (0.742 ± 0.107), which were significantly higher than those in stage Ⅰ~Ⅱ and well differentiated lung cancer tissues (P<0.05); there were no significant difference in the relative expression of MAGE-As mRNA in different gender, age, tumor diameter and pathological type (P>0.05). The median overall survival of patients with high and low MAGE-As mRNA expression in lung cancer tissues was 33 and 44 months, with a difference in survival between patients with high and low MAGE-As mRNA expression (P<0.05). The difference in median overall survival between patients with high and low MAGE-As protein expression was not statistically significant (P>0.05). Conclusion: The expression of MAGE as protein and mRNA are up-regulated in non-small cell lung cancer, is related to the severity of the disease, and the prognosis of patients with high expression of MAGE As mRNA is poor.

Key words： Melanoma associated antigen As Protein mRNA Non-small cell lung cancer

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2023.06.011 OR http://www.hbyxzzs.cn/EN/Y2023/V29/I6/937

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