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| Effect of Inhaled Coricosteroids on Serum TNF-α HDAC2 and PTX3 Levels in Hospitalized Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease |
| LIU Ting, LI Yang, SHI Zhihong, et al |
| The First Affiliated Hospital of Xi'an Jiaotong University, Shaanxi Xi'an 710061, China |
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Abstract Objective: To observe the effects of inhaled coricosteroids on the levels of serum tumor necrosis factor-α (TNF-α), histone deacetylase 2 (HDAC2) and pentraxin 3 (PTX3) in hospitalized patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods: One hundred and thirty patients with AECOPD admitted to our hospital from January 2020 to December 2021 were selected and divided into two groups using the coin toss grouping method. Both groups were given conventional symptomatic treatment, the control group was additionally given terbutaline nebulizer inhalation treatment, and the observation group was treated with combined inhaled corticosteroids on the basis of the control group. The differences of symptom and sign scores, pulmonary function, blood routine, TNF-α, HDAC2 and PTX3 were compared between the two groups, and the adverse effects were counted in both groups. Results: Before treatment, there was no statistically significant difference between the two groups in terms of symptom and sign scores and pulmonary function (P>0.05). Compared with before treatment, the scores of cough, sputum, shortness of breath, and lung auscultation decreased after treatment in both groups, and the decrease values were greater in the observation group before and after treatment than in the control group (P<0.05). The first second force expiratory volume (FEV1) and FEV1/forced vital capacity (FVC) increased after treatment in both groups, and the increased values were greater in the observation group before and after treatment than in the control group (P<0.05).Before treatment, there were no statistically significant differences in TNF-α, HDAC2, PTX3, and routine blood indices between the two groups (P>0.05). Compared with before treatment, neutrophil percentage (NE%), TNF-α, neutrophil-to-lymphocyte ratio (NLR), HDAC2, white blood cell count (WBC), and PTX3 decreased after treatment in both groups, and the decrease value was greater in the observation group before and after treatment than in the control group (P<0.05). Lymphocyte percentage (LY%) increased in both groups after treatment, and the increase was greater in the observation group before and after treatment than in the control group (P<0.05). Two cases of hoarseness and one case of hoarseness occurred in the control group and the observation group, respectively, and no adverse reactions such as pharyngeal discomfort and blood glucose elevation occurred.Conclusion: Inhaled coricosteroids for AECOPD can reduce symptoms such as cough and sputum and improve lung function, which may be related to reducing the expression of TNF-α, HDAC2 and PTX3.
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2023, Vol. 29 
