|
|
|
| Analysis of the Current Situation of Patients with Nephrotic Syndrome Complicated by Acute Kidney Injury and Its Factors |
| CHEN Qingmiao, CHEN Yueyao, ZHOU Shiqun, et al |
| Danzhou People's Hospital, Hainan Danzhou 571799, China |
|
|
|
|
Abstract Objective: To observe the occurrence of acute kidney injury in patients with nephrotic syndrome and analyze the factors that may lead to the occurrence of acute kidney injury in patients, and to guide the development of clinical intervention countermeasures in order to reduce the risk of acute kidney injury. Methods: One hundred and twenty patients with nephrotic syndrome admitted to our hospital between January 2020 and January 2022 were included in the study, and the patients were divided into the occurrence group and the non-occurrence group based on the presence or absence of acute kidney injury, and the baseline data of the two groups were compared to analyze the factors that may lead to the occurrence of acute kidney injury in patients.Results: Among the 120 patients with nephrotic syndrome enrolled, 32 patients had acute kidney injury, including 15 patients of grade 1, 12 patients of grade 2, and 5 patients of grade 3; 88 patients did not have acute kidney injury; compared with the non-occurrence group, the occurrence group had higher age (≥60 years), use of low molecular dextrose (yes), co-infection (yes), irrational use of diuretics (yes), use of glucocorticoids (yes), creatinine ( ≥353.6 umol/L), and urea nitrogen (≥8.0 mmol/L) accounted for a higher proportion, and serum NGAL, IL-18, and neutrophil count were highly expressed (P<0.05); other data were compared between groups (P>0.05); the results of binomial logistic regression analysis showed that age (≥60 years), use of low-molecular dextro-anhydride (yes), co-infection (yes), irrational use of diuretics (yes), use of glucocorticoids (yes), creatinine (≥353.6 umol/L), and urea nitrogen (≥8.0 mmol/L) were all higher, and high expression of serum NGAL, IL-18, and neutrophil count were all influential factors in the development of acute kidney injury in patients with nephrotic syndrome (OR>1, P<0.05). Conclusion: Age, use of low molecular dextran, co-infection, irrational use of diuretics, use of glucocorticoids, creatinine, urea nitrogen, serum NGAL, IL-18, and neutrophil count are all important factors contributing to the increased risk of acute kidney injury in patients with nephrotic syndrome.
|
|
|
|
|
|
[1] Jung J,Lee J H,Park Y S.Therapeutic response and long-term renal outcomes in childhood idiopathic steroid-resistant nephrotic syndrome:a single-center study[J].Nephron,2022,146(4):327-334.
[2] 李学旺.成人原发性肾病综合征治疗专家共识[M].人民卫生出版社,2011.
[3] Panaput T,Peerapornratana S,Sirivongrangson P ,et al.Modalities of renal replacement therapy and clinical outcomes of patients with acute kidney injury in a resource-limited setting:results from a SEA-AKI study[J].Crit Care,2021,65(4):18-25.
[4] 贾丽芳,周培-,白文英.慢性肾脏病患者经皮冠脉介入术后急性肾损伤危险因素分析[J].中国中西医结合肾病杂志,2022,23(3):231-233.
[5] 周燕琳.成人原发肾病综合征并发急性肾损伤危险因素分析及预测模型建立[D].重庆医科大学第一临床学院,2020.
[6] 卿山林,何敬东,任波.微小病变型肾病综合征合并急性肾损伤患者临床及病理特征分析[J].临床误诊误治,2020,33(9):82-86.
[7] 汪水连.青少年肾病综合征合并急性肾损伤病理与临床特征分析[J].新疆医科大学学报,2020,43(6):763-767.
[8] 周燕琳,杜晓刚.成人原发肾病综合征并发急性肾损伤危险因素分析[J].中国医学科学院学报,2020,42(4):436-443.
[9] 向瑞,李振江.中性粒细胞明胶酶相关脂质运载蛋白在急性肾损伤中的研究进展和应用评价[J].中国中西医结合肾病杂志,2020,21(1):84-86.
[10] 胡晓宁,耿静,郎哲,等.血清NGAL和PCT对脓毒症相关急性肾损伤的评估及临床意义的研究[J].临床急诊杂志,2020,21(9):696-700. |
|
|
|
2023, Vol. 29 
