肠道益生菌辅治支气管哮喘患儿的效果及其作用机制

doi:10.3969/j.issn.1006-6233.2023.04.014

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Abstract Objective: To investigate the effect of enteric probiotics supplementation in children with bronchial asthma and its mechanism of action. Methods: A total of 105 children with bronchial asthma admitted to our hospital from January 2019 to January 2022 were randomly divided into routine group (52 cases) and probiotic group (53 cases). The routine group was given routine treatment, and the probiotic group was given intestinal probiotics adjuvant treatment on the basis of routine treatment. The two groups were detected the differences of intestinal flora, immune function and sputum eosinophil percentage (EOS%), integrin α4β1 and αvβ6 before and after treatment, and the adverse effects and the number of acute attacks within 6 months were counted. Results: Before treatment, there was no significant difference in intestinal flora between the two groups (P>0.05). After treatment, bifidobacterium and lactobacillus in probiotics group were higher than before, while Escherichia coli was lower. There was no statistical significance in intestinal flora in conventional group compared with before treatment (P>0.05). The difference values of bifidobacterium, lactobacillus and Escherichia coli before and after treatment in probiotic group were larger than those in conventional group (P<0.05). Before treatment, there were no significant differences in sputum EOS%, integrin α4β1, αvβ6 and immune function between the two groups (P>0.05). After treatment, CD8 Anhui+, EOS% of sputum, integrin α4β1, αvβ6 were decreased, and CD4 Anhui+, CD4 Anhui+/CD8 Anhui+ were increased in both groups (P<0.05). The difference before and after treatment in probiotic group was larger than that in conventional group (P<0.05). There were 3 cases of adverse reaction in probiotics group, the incidence was 5.66%, and the adverse reaction rate was not statistically significant compared with 11.54% in conventional group (P>0.05). During the 6-month follow-up, the number of acute attacks in the probiotic group (0.41±0.16) was significantly lower than that in the conventional group (0.87±0.23), and the difference was statistically significant (P<0.05). Conclusion: Intestinal probiotics in the adjuvant treatment of bronchial asthma can improve the immune function of children and reduce the number of acute attacks. The possible mechanism is related to improving the structure of intestinal flora and reducing the expression of EOS%, integrin α4β1 and αvβ6 in sputum.

Key words： Enteric probiotics Bronchial asthma Intestinal flora

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	Articles by authors
	MA Qibo
	ZHAN Feng
	ZHONG Chong
	et al

Cite this article:

MA Qibo,ZHAN Feng,ZHONG Chong, et al. Effectiveness of Enteric Probiotic Supplementation in the Treatment of Children with Bronchial Asthma and Its Mechanism of Action[J]. HeBei Med, 2023, 29(4): 595-600.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2023.04.014 OR http://www.hbyxzzs.cn/EN/Y2023/V29/I4/595

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