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| Effects of Selective α-2 Agonists on Patients Undergoing Carotid Endarterectomy and Their Cerebral Protective Effects |
| ZHAO Zhenru, SU Bin, WANG Liping, et al |
| Chengde Central Hospital, Hebei Chengde 067000, China |
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Abstract Objective: To investigate the effects of selective α-2 receptor agonists dexmedetomidine on inflammation, oxidative stress and brain functions in patients undergoing carotid endarterectomy. Methods: A total of 60 patients who underwent carotid endarterectomy in our hospital from January 2018 to December 2021 were randomly divided into control group and observation group. The observation group was given dexmedetomidine anesthesia, and the control group was given routine anesthesia. The neurological function of the two groups were compared. Serum inflammatory factor TNFα, ICAM-1 and oxidative stress factor MDA, IL-6, S100β, neural function markers BDNF, TGF-β1,NSE, were detected. Results: The decreases of TNFα, IL-6, ICAM-1, MDA, S100β and NSE in the observation group was significantly higher than the control group(P＜0.05). MMSE score, BDNF, and TGF-β1 in the observation group were significantly higher than in the control group(P＜0.05). Conclusion: The selective α-2 receptor agonists dexmedetomidine could inhibit inflammation and oxidative stress, and protect brain functions.
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[1] Lee TH.Management of carotid artery stenosis[J].Acta Neurol Taiwan,2021,30(4):123-127.
[2] Heck D,Jost A.Carotid stenosis,stroke,and carotid artery revascularization[J].Prog Cardiovasc Dis,2021,65(3-4):49-54.
[3] Cooper AS.Carotid endarterectomy for symptomatic carotid stenosis[J].Crit Care Nurse,2021,41(6):76-78.
[4] Baiu I,Stern JR.Carotid artery endarterectomy[J].JAMA,2020,324(1):110.
[5] Nelson P,Bustillo M.Anesthesia for carotid endarterectomy,angioplasty,and stent[J].Anesthesiol Clin,2021,39(1):37-51.
[6] Lee S.Dexmedetomidine:present and future directions[J].Korean Anesthesiol,2019,72(4):323-330.
[7] Lin N,Vutskits L,Bebawy JF,et al.Perspectives on dexmedetomidine use for neurosurgical patients[J].Neurosurg Anesthesiol,2019,31(4):366-377.
[8] Yuan D,Liu Z,Kaindl J,et al.Activation of the alpha(2B) adrenoceptor by the sedative sympatholytic dexmedetomidine[J].Nat Chem Biol,2020,16(5):507-512.
[9] Sellas MN,Kyllonen KC,Lepak MR,et al.Dexmedetomidine for the management of postoperative pain and sedation in newborns[J].Pediatr Pharmacol Ther,2019,24(3):227-233.
[10] Huang W,Xiao FL,Huang WJ,et al.MicroRNA-29a-3p strengthens the effect of dexmedetomidine on improving neurologic damage in newborn rats with hypoxic-ischemic brain damage by inhibiting HDAC4[J].Brain Res Bull,2021,167(2):71-79.
[11] Ge YL,Li Q,Nie YY,et al.Dexmedetomidine improves cognition after carotid endarterectomy by inhibiting cerebral inflammation and enhancing brain-derived neurotrophic factor expression[J].Int Med Res,2019,47(6):2471-2482. |
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2023, Vol. 29 
